Does Lupus and Angiokeratoma Affect Male Sperm Motility? - Urology

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Systemic lupus erythematosus (SLE)


Does having both systemic lupus erythematosus (controlled by medication) and angiofibroma (on the scrotum) affect sperm motility in men? A physician once mentioned that it could impact sperm motility.
Even though the condition is currently managed with medication, could it still have an effect?

Niming D, 30~39 year old female. Ask Date: 2020/09/26

Dr. Du Shixi reply Urology


Hello: Systemic lupus erythematosus is complex, with various pathogenic causes and classifications that may not be uniformly addressed.
It is recommended to conduct a sperm analysis for a more objective assessment.
Wishing you good health.

Reply Date: 2020/09/26

More Info


Lupus, specifically systemic lupus erythematosus (SLE), is an autoimmune disease that can have various systemic effects on the body, including potential impacts on male reproductive health. Angiokeratomas, on the other hand, are benign vascular lesions that can appear on the skin, including the scrotum, and are generally not associated with significant systemic health issues.
When considering the effects of lupus on sperm motility, it is important to understand that lupus can lead to several complications that may indirectly affect male fertility. For instance, lupus can cause chronic inflammation, which may lead to hormonal imbalances or affect the overall health of the reproductive system. Additionally, certain medications used to manage lupus, such as corticosteroids or immunosuppressants, can also have side effects that may impact sperm production and motility.
Research indicates that men with autoimmune diseases, including lupus, may experience alterations in sperm parameters, including motility, morphology, and concentration. This is thought to be due to the inflammatory processes associated with the disease, which can affect the testicular environment and sperm production. Furthermore, the presence of autoantibodies in lupus patients may also play a role in affecting sperm function.

Regarding angiokeratomas, these lesions are typically harmless and do not have a direct impact on sperm motility or fertility. However, if there is significant discomfort or if they are associated with other underlying conditions, it may warrant further investigation.
In your case, since you mentioned that your lupus is under control with medication, it is possible that the direct impact on sperm motility may be minimized. However, the underlying disease process and any residual effects from previous inflammation or medication side effects could still play a role. It is also worth noting that individual responses to lupus and its treatment can vary significantly, and some men may experience more pronounced effects on fertility than others.

To assess the current state of your sperm motility, a semen analysis would be beneficial. This test can provide valuable information about sperm concentration, motility, and morphology, allowing for a clearer understanding of your reproductive health. If there are concerns about the impact of lupus or any medications on your fertility, discussing these with a healthcare provider specializing in reproductive health or a urologist can provide tailored advice and potential treatment options.

In summary, while lupus can potentially affect sperm motility due to its systemic effects and the medications used for treatment, angiokeratomas are unlikely to have any direct impact on fertility. Continuous monitoring of your reproductive health through semen analysis and consultations with specialists can help manage any concerns you may have regarding fertility and sperm motility.

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