Can Ankylosing Spondylitis Cause Stomach Pain? Exploring the Connection - Internal Medicine

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Does ankylosing spondylitis accompany stomach pain?


During my military service, I tested positive for a blood test and was diagnosed, but I haven't seen a specialist in this area for the past ten years.
The pain I experience is located in the center of my lower back, along the spinal cord.
Whenever I have this pain, I also experience stomach pain, which can lead to vomiting, sometimes to the point of vomiting bile.
Additionally, if I have an upset stomach, the pain in my spine becomes unbearable.
These two issues seem to occur simultaneously.
I have undergone gastroscopy and colonoscopy, both of which showed no problems.
In the past two years, I have been visiting doctors more frequently, but about 70% of them say there is no connection between these two issues.
Currently, I am taking Celecoxib 200 mg; I take it when I have pain, and it usually alleviates the discomfort, although there are times when it is ineffective.
My fellow patients mention experiencing stiffness in the morning, but I do not have that.
My symptoms seem to flare up mainly due to significant weather changes or after sitting for extended periods.
I would like to ask the doctor if I truly have ankylosing spondylitis (even though I have been diagnosed) since my symptoms seem somewhat different.
Should I continue taking the medication regularly, or only when I am in pain? Thank you.

A-Kai, 40~49 year old female. Ask Date: 2020/10/07

Dr. Zeng Guosen reply Internal Medicine


Hello, a positive HLA-B27 test does not necessarily indicate that you have ankylosing spondylitis.
The most important factors for diagnosis are: 1.
Do your symptoms match? 2.
Is there evidence of sacroiliitis on X-ray? Ankylosing spondylitis is not directly related to stomach pain, unless it is due to medication side effects or associated inflammatory bowel disease (IBD).
It is recommended to consult a rheumatologist.
Thank you for your question.

Reply Date: 2020/10/07

More Info


Ankylosing Spondylitis (AS) is a type of inflammatory arthritis that primarily affects the spine and the sacroiliac joints in the pelvis. It can lead to chronic pain and stiffness in the back and neck. However, many patients with AS also report gastrointestinal symptoms, including stomach pain, nausea, and even vomiting. This connection can be complex and multifaceted.

Firstly, it is important to understand that AS is associated with systemic inflammation. This means that the inflammatory processes that affect the spine can also impact other organs, including the gastrointestinal tract. In some cases, patients with AS may develop inflammatory bowel disease (IBD), which includes conditions like Crohn's disease and ulcerative colitis. These conditions can cause abdominal pain, diarrhea, and other gastrointestinal symptoms. While you mentioned that you have undergone endoscopy and colonoscopy without any findings, it is still possible for gastrointestinal symptoms to arise from the inflammatory processes associated with AS.

Moreover, the pain you experience in your stomach could also be related to the medications you are taking. For instance, non-steroidal anti-inflammatory drugs (NSAIDs), which are commonly used to manage pain in AS, can irritate the stomach lining and lead to gastritis or ulcers, causing abdominal pain and nausea. If you are taking medications like Celecoxib (as you mentioned "希樂葆"), it is crucial to monitor for any gastrointestinal side effects. If you notice a correlation between your medication and stomach pain, it would be wise to discuss this with your healthcare provider.

Additionally, the symptoms you describe, such as vomiting bile, could indicate a more serious gastrointestinal issue, such as a blockage or severe gastritis. Even if previous tests have shown no abnormalities, if your symptoms persist or worsen, further evaluation may be warranted. It might be beneficial to consult a gastroenterologist who can provide a more specialized assessment of your gastrointestinal symptoms.

Regarding your question about whether to take medication continuously or only when in pain, this is a common dilemma for many patients with chronic conditions. Some patients find that taking medication regularly helps to manage their symptoms more effectively and prevents flare-ups, while others prefer to take medication only when they experience significant pain. This decision often depends on the severity of your symptoms, the side effects of the medication, and your overall treatment plan. It is essential to have an open discussion with your rheumatologist about your treatment strategy, as they can help tailor a plan that addresses both your AS and any gastrointestinal concerns.

Lastly, while you may not experience morning stiffness, which is a hallmark symptom of AS, it is important to remember that the disease can manifest differently in each individual. The variability in symptoms does not negate your diagnosis. If you feel that your symptoms are not aligning with typical AS presentations, it is worth discussing this with your rheumatologist. They may consider adjusting your treatment plan or exploring other potential diagnoses that could explain your symptoms.

In conclusion, while there may not be a direct correlation between Ankylosing Spondylitis and stomach pain for every patient, the inflammatory nature of AS can indeed lead to gastrointestinal symptoms. It is crucial to monitor your symptoms closely, communicate with your healthcare providers, and consider both your rheumatological and gastrointestinal health in your treatment plan.

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