Is PRP Treatment Safe for Patients with a Cancer History? - Oncology

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Is it appropriate for patients with a history of cancer to undergo PRP (Platelet-Rich Plasma) therapy?


Hello, Doctor.
I was diagnosed with stage I colon cancer six years ago and underwent surgical treatment without chemotherapy.
My follow-up has been smooth since then.
I am also a carrier of hepatitis B and have been under regular monitoring.
Due to my love for sports, I have developed osteoarthritis in my knees from overuse, and my orthopedic doctor has suggested PRP (platelet-rich plasma) therapy, believing that my medical history would not affect the treatment.
Since you are an expert in oncology, I would like to ask if this treatment is suitable for my situation.
I am inclined towards actively treating my knees, especially since I am still young, but I am also concerned about the possibility of causing irreversible harm, which is quite troubling.

A-Hsiung, 40~49 year old female. Ask Date: 2020/10/08

Dr. Chen Sirong reply Oncology


Ah Xiong / 47 years old / Male believes that the so-called PRP is an intra-articular injection, not a systemic blood injection.
Therefore, I personally think it is acceptable.
Wishing you swift recovery, Chen Si-Rong, Taoyuan Hospital.

Reply Date: 2020/10/08

More Info


When considering the safety of Platelet-Rich Plasma (PRP) treatment for patients with a history of cancer, it is essential to evaluate several factors, including the type of cancer, the treatment history, and the current health status of the patient. In your case, you have a history of stage I colon cancer that was surgically treated six years ago, and you have not undergone chemotherapy. Additionally, you are a carrier of Hepatitis B and are under regular monitoring for that condition.
PRP therapy involves the injection of a concentration of platelets derived from the patient's own blood into the affected area, in this case, the knee joint, to promote healing and reduce inflammation. The procedure is generally considered safe because it uses the patient's own biological material, which minimizes the risk of allergic reactions or infections. However, the implications of a cancer history must be carefully considered.

1. Cancer History: Although your colon cancer was treated successfully and has not recurred, it is crucial to consult with your oncologist before proceeding with PRP therapy. Some studies suggest that growth factors released from platelets could potentially stimulate the growth of residual cancer cells, although this risk is generally considered low, especially in patients who have been cancer-free for several years. Your oncologist can provide personalized advice based on your specific medical history and current health status.

2. Hepatitis B Status: As a Hepatitis B carrier, it is also important to ensure that your liver function is stable before undergoing any procedure, including PRP therapy. Hepatitis B can affect your body's ability to heal and respond to treatments, so discussing your liver health with a hepatologist or your primary care physician is advisable.

3. Knee Osteoarthritis: Given your active lifestyle and the development of osteoarthritis due to overuse, PRP therapy may provide symptomatic relief and improve function in your knee. Many patients report positive outcomes from PRP injections, including reduced pain and improved mobility. However, the effectiveness can vary, and it may take several weeks to notice significant improvements.

4. Consultation with Specialists: Since your orthopedic surgeon has suggested PRP therapy and believes it will not adversely affect your cancer history, it is essential to have an open dialogue with both your orthopedic surgeon and oncologist. They can work together to assess the risks and benefits of the treatment in your specific case.

5. Monitoring and Follow-Up: If you decide to proceed with PRP therapy, ensure that you have a plan for monitoring your health closely. Regular follow-ups with your healthcare providers will help catch any potential issues early.

In conclusion, while PRP therapy may be a viable option for treating your knee osteoarthritis, it is crucial to involve your oncologist in the decision-making process. They can help assess any potential risks associated with your cancer history and provide guidance tailored to your unique situation. Ultimately, the goal is to manage your knee pain effectively while ensuring your overall health and safety.

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