HPV in Men: Diagnosis, Treatment, and Prevention - Urology

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Male HPV Infection


Hello Doctor, last year I discovered a lump beneath my scrotum and, fearing it might be genital warts, I immediately consulted a doctor for an examination.
After the examination, the doctor determined it was not genital warts, and I have not had it checked since.
The lump has not increased in size over the past year.
However, during a recent health check, my SCC index showed abnormalities.
After researching online, I found it might be related to HPV, so I promptly went to a medical laboratory for HPV testing.
During the testing process, a hard brush was used to sample the penis, scrotum, and especially the lump, which was brushed multiple times.
The results came back positive for HPV (types: 51/58/68, viral load ++).
Consequently, I immediately scheduled an appointment at a hospital.
The doctor visually examined the lump and performed an acetic acid test, stating that it was not genital warts.
However, if I wanted to remove it, I would need to have regular treatments with a chemical agent (which would cause a burning sensation).
After several treatments, the lump did not disappear, so I consulted two more doctors.
One doctor believed it was not genital warts and that I only needed treatment for the existing scrotal eczema, thus not prescribing any treatment.
The other doctor believed it was a wart and immediately performed cryotherapy.
I would like to ask the doctor: 1.
Is it possible for genital warts on the scrotum to be caused by high-risk HPV types other than 6 and 11? 2.
Can genital warts appear as a single lump and remain unchanged for a year? 3.
Based on the appearance of the lump (as shown in a photo taken about a month ago) https://imgur.com/a/lpfHOBR, what do you think it is? 4.
After recent cryotherapy, the lump has changed to this appearance https://imgur.com/a/K8JZXJa; is this normal? 5.
What is the difference between genital warts and other types of warts? 6.
What precautions should I take during the treatment of genital warts to avoid recurrent infections? 7.
Can I purchase over-the-counter treatments like Aldara on my own, or is it better to have a doctor prescribe medication? I apologize for the lengthy message and numerous questions, and I sincerely appreciate your assistance in clarifying these issues.
Thank you!

Mr. Lin, 30~39 year old female. Ask Date: 2020/10/14

Dr. Du Shixi reply Urology


Hello:
1.
Is it possible that genital warts on the scrotum could be caused by HPV types other than 6 and 11 (such as high-risk types found in my lab tests)? --> It is possible.

2.
Is it possible for a wart to appear as a single lesion and not change for a year? --> Yes, it is possible; some patients experience this.

3.
Before treatment, the lesions looked like this (photo taken about a month ago) https://imgur.com/a/lpfHOBR.
What do you think, doctor? --> It is possible, but other viruses (not HPV) could also cause this.

4.
After recent cryotherapy, the lesions look like this https://imgur.com/a/K8JZXJa.
Is this normal? --> Cryotherapy is a destructive treatment, and this can happen.

5.
What is the difference between genital warts and condyloma? --> Condyloma is a colloquial term; warts are skin infections caused by the human papillomavirus (HPV) that can occur on the face, genital area, or extremities.

6.
What should I pay attention to in order to avoid recurrent infections of genital warts? If they appear, they need to be treated, and also pay attention to immune system health.

7.
Can I buy over-the-counter creams like Aldara to treat this myself, or is it better to get a prescription from a doctor at a hospital? --> It is recommended to go to a major hospital; make sure to read the instructions carefully before use.
Wishing you good health.

Reply Date: 2020/10/14

More Info


Understanding HPV in men is crucial, especially given the rising awareness of its implications for both male and female health. Human Papillomavirus (HPV) is a common sexually transmitted infection that can lead to various health issues, including genital warts and certain types of cancer. Here, I will address your specific questions and provide a comprehensive overview of HPV in men, including diagnosis, treatment, and prevention strategies.

1. Can genital warts be caused by non-6 and 11 HPV types?
Yes, genital warts are primarily associated with low-risk HPV types, particularly types 6 and 11. However, high-risk HPV types, such as 51, 58, and 68, can also cause lesions that may not present as typical warts. While these high-risk types are more commonly linked to cancers (like penile or anal cancer), they can still contribute to abnormal growths in the genital area. Therefore, it is essential to monitor any unusual growths, regardless of the HPV type involved.

2. Is it possible for warts to appear as a single lesion and remain unchanged for a year?
Yes, it is possible for genital warts to manifest as a solitary lesion and remain stable for an extended period. HPV can behave variably; some individuals may develop multiple warts, while others may only have one. The immune system plays a significant role in controlling the virus, and in some cases, the body may suppress the virus effectively, leading to a stable lesion.

3. What could the lesion you described be?
Without visual examination, it is challenging to provide a definitive diagnosis. However, based on your description and the fact that it has been evaluated by multiple healthcare providers, it could be a benign lesion, such as a seborrheic keratosis or a follicular cyst, especially if it has not changed over time. The fact that it was not identified as a wart by some doctors suggests that it may not be a typical manifestation of HPV.

4. Is the post-freezing appearance of the lesion normal?
After cryotherapy, it is common for treated lesions to appear swollen, red, or blistered. This reaction is part of the healing process as the body responds to the treatment. If the lesion continues to change or does not improve, follow up with your healthcare provider for further evaluation.

5. What is the difference between genital warts and other types of lesions?
Genital warts, caused by low-risk HPV types, typically appear as soft, fleshy growths that can be raised or flat. In contrast, other lesions, such as those caused by high-risk HPV types, may not have the same appearance and can be more subtle. Additionally, high-risk HPV types are associated with precancerous changes and cancers, while low-risk types are primarily associated with benign warts.

6. What precautions should be taken to avoid recurrent infections?
To prevent recurrent infections, it is essential to maintain good genital hygiene, avoid sexual contact during outbreaks, and consider vaccination against HPV. The HPV vaccine can protect against the most common high-risk and low-risk types. Regular check-ups with your healthcare provider for monitoring and treatment are also crucial.

7. Is it advisable to self-treat with over-the-counter medications like Aldara?
While some over-the-counter treatments are available for genital warts, it is generally recommended to consult with a healthcare provider before starting any treatment. Self-treatment may not be effective or appropriate for all types of lesions, and a healthcare provider can offer guidance on the most suitable treatment options based on your specific condition.

In conclusion, HPV is a complex virus with various implications for men's health. Regular check-ups, awareness of symptoms, and preventive measures, including vaccination, are essential for managing HPV effectively. If you have concerns about your health or the lesions you are experiencing, it is crucial to maintain open communication with your healthcare provider for tailored advice and treatment options.

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