HPV Infection: Symptoms, Treatment, and Prevention Options - Dermatology

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HPV virus infection


Hello Doctor,
The patient is a 34-year-old male, 176 cm tall and weighing 71 kg, with no known drug allergies or harmful habits.
The symptoms have been present for two weeks.
The situation is as follows: My partner and I were infected with HPV at the beginning of the year, and both of us had lesions in our genital areas.
After undergoing cryotherapy for six months, there were no recurrences.
However, in early September, my partner discovered several raised lesions near the abdomen on the penis and on the scrotum, as shown in the images: http://i.imgur.com/9cKsAum.jpg and http://i.imgur.com/VuzlCXZ.jpg.
Additionally, there are two lesions on the inner side of the penis, the nature of which is uncertain: http://i.imgur.com/nsREJgO.jpg.

I would like to ask the doctor if this is indeed genital warts (condylomata acuminata)? Some dermatologists have said it is, while others have disagreed.
I would like to know your opinion.
Should we investigate the source of the infection? (Since we are in a monogamous relationship.) Is it necessary to test for the type of HPV infection? (I am concerned about high-risk HPV strains.) Currently, we are undergoing cryotherapy, but there have been recurrences.
I would like to know if there is a way to achieve a complete cure or prevention, such as using topical treatments or medications.
This condition has caused significant psychological distress for the patient, and I hope the doctor can provide a professional explanation.
Thank you very much, and I greatly appreciate your help.

JJ, 30~39 year old female. Ask Date: 2013/09/12

Dr. Wu Yuxin reply Dermatology


Based on the images, it can be challenging to establish a diagnosis due to the small size of the lesions.
The first and third images indeed raise suspicion, while the second image appears to show a hemangioma on the scrotum.
The source is uncertain, as the incubation period can range from several months to years.
Currently, the preferred treatments are cryotherapy or electrosurgery; however, combining these with Aldara cream (Imiquimod, 3M) can significantly enhance the cure rate.
For prevention, avoiding exposure to infections is paramount.
Existing studies indicate that vaccination against cervical cancer can also help prevent infections, but a professional evaluation by a physician is still necessary for guidance.

Reply Date: 2013/09/12

More Info


Understanding HPV Infection: Symptoms, Treatment, and Prevention Options
Human Papillomavirus (HPV) is a common sexually transmitted infection that can lead to various health issues, including genital warts and certain types of cancer. Given your situation, let's break down the key aspects of HPV infection, its symptoms, treatment options, and preventive measures.


Symptoms of HPV Infection
HPV infections can be asymptomatic, meaning many individuals may not show any signs or symptoms. However, when symptoms do occur, they may include:
1. Genital Warts: These are soft, fleshy growths that can appear on the genital area, including the vulva, vagina, cervix, penis, scrotum, and anus. They can be raised or flat, single or multiple, and vary in size.

2. Cervical Changes: In women, certain high-risk HPV types can cause changes in cervical cells, leading to conditions like cervical intraepithelial neoplasia (CIN), which can progress to cervical cancer if left untreated.

3. Other Symptoms: In some cases, HPV can lead to throat or mouth cancers, particularly in individuals who engage in oral sex with an infected partner.


Treatment Options
1. Genital Warts: If you or your partner have been diagnosed with genital warts, treatment options include:
- Topical Treatments: Prescription creams such as imiquimod or podofilox can be applied directly to the warts.

- Cryotherapy: This involves freezing the warts with liquid nitrogen, which you mentioned has been done in your case.

- Surgical Options: In some instances, warts may need to be surgically removed if they are persistent or causing discomfort.

2. Cervical Changes: If there are abnormal cervical cells (e.g., CIN), your healthcare provider may recommend:
- Monitoring: Regular Pap smears and HPV testing to track any changes.

- Procedures: Such as LEEP (Loop Electrosurgical Excision Procedure) to remove abnormal cells.


Preventive Measures
1. HPV Vaccination: The HPV vaccine (Gardasil 9) is highly effective in preventing infections from the most common high-risk HPV types (16, 18, 31, 33, 45, 52, and 58) and low-risk types (6 and 11) that cause genital warts. It is recommended for both males and females, ideally before becoming sexually active. Even if you have been infected with one type of HPV, the vaccine can still protect against other types.

2. Safe Sex Practices: Using condoms can reduce the risk of HPV transmission, although they do not provide complete protection since HPV can infect areas not covered by a condom.

3. Regular Screening: For women, regular Pap smears and HPV testing are crucial for early detection of any cervical changes. The American College of Obstetricians and Gynecologists recommends starting Pap tests at age 21, regardless of sexual history.


Addressing Your Concerns
Regarding the bumps you mentioned on your partner's genital area, it is essential to have a healthcare provider evaluate them. While some dermatologists may identify them as genital warts, others may not. A definitive diagnosis often requires a visual examination and possibly a biopsy.

If there is concern about high-risk HPV types, testing can be done to identify the specific strain. This information can guide treatment and monitoring strategies.
As for recurrence, it is not uncommon for genital warts to return after treatment. Continuous monitoring and follow-up with a healthcare provider are essential.
Lastly, addressing the psychological burden of HPV is important. Support groups and counseling can provide emotional support for both partners dealing with the implications of HPV.

In conclusion, while HPV can be concerning, understanding the infection, its treatment, and preventive measures can empower you and your partner to manage the situation effectively. Regular check-ups and open communication with healthcare providers are key to navigating this health issue.

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