Sebaceous Gland Disorders: Symptoms and Specialist Guidance - Internal Medicine

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Sebaceous gland abnormalities


Symptoms: 1.
Several small white spots on the inner side of the lips (appeared at the end of October, confirmed by a dentist as sebaceous glands).
2.
Dense small white spots on the upper eyelids and around the eyes (have been present for some time, confirmed by an ophthalmologist as also a sebaceous issue) (during this period, I have been taking medication for polycystic ovary syndrome, with no improvement).
3.
Chalazion (has occurred once or twice in the past year, but the frequency has increased recently).
4.
Small blisters and follicles inside the eye (recently appeared, the ophthalmologist said that no treatment is needed in ophthalmology; if I want to find the cause, I can consult gynecology, hepatology, or nephrology).
5.
Increased acne (had it since childhood, but it has abnormally increased in the last two months).
6.
Weight loss of 8 kilograms over the past six months (no special exercise, just eating less).
Past & known medical conditions: 1.
Polycystic ovary syndrome (returned for a follow-up in May this year; ultrasound and blood tests were normal, medication has been stopped).
2.
Significant hair loss, over 250 strands per day (consulted a dermatologist; aside from slight iron deficiency, everything else is normal, no medication used, the doctor recommended dietary supplements).
3.
Benign cysts in the breast (regularly monitored by surgery).
Although sebaceous issues do not require aggressive treatment or medication, they are quite bothersome, and currently, the white spots on my lips are relatively few.
I am afraid they will develop into a large area like those on my eyelids, so I want to see a doctor to find out what is wrong with me (mainly to address the sebaceous issue).
Should I consult a metabolic specialist, gynecologist, hepatologist, nephrologist, or another specialty? Thank you.

Anita, 30~39 year old female. Ask Date: 2020/11/04

Dr. Li Jian reply Internal Medicine


Excessive hair loss and weight loss can be evaluated for thyroid function abnormalities, while sebaceous gland issues should be referred to a dermatologist.

Reply Date: 2020/11/04

More Info


Understanding sebaceous gland disorders can be quite complex, especially when symptoms manifest in various forms, as you have described. The symptoms you are experiencing, such as small white spots on the inner lips and eyelids, increased frequency of styes (chalazia), and a rise in acne, suggest a potential dysfunction of the sebaceous glands, which are responsible for producing sebum, an oily substance that helps to keep the skin moisturized.

The presence of small white spots, often referred to as milia or sebaceous cysts, can occur when the sebaceous glands become blocked or overactive. These can be benign and often do not require treatment unless they become bothersome or infected. However, your concern about the progression of these spots, especially on your eyelids, is valid. The fact that you have a history of polycystic ovary syndrome (PCOS) may also play a role in your symptoms, as hormonal imbalances associated with PCOS can lead to increased oil production and acne.

In terms of the increased frequency of styes, this could be related to the blockage of the meibomian glands, which are a type of sebaceous gland located in the eyelids. When these glands become clogged, it can lead to inflammation and the formation of styes. The appearance of small water blisters and follicles in the eye area is also concerning and may warrant further investigation, particularly to rule out any underlying conditions related to your ovarian, liver, or kidney health, as suggested by your ophthalmologist.

Given your symptoms and medical history, it would be prudent to consult with a dermatologist who specializes in skin and sebaceous gland disorders. A dermatologist can provide a thorough examination of your skin and eyes, assess the severity of your symptoms, and recommend appropriate treatments. They may suggest topical treatments to manage the sebaceous gland activity, such as retinoids or other acne medications, and can also provide guidance on skincare routines that may help alleviate your symptoms.

Additionally, since you have a history of PCOS, it may be beneficial to consult with an endocrinologist or a gynecologist who specializes in hormonal disorders. They can evaluate your hormonal levels and determine if there are any underlying hormonal imbalances contributing to your skin issues. Managing PCOS effectively can often lead to improvements in skin conditions, including acne and sebaceous gland disorders.

In summary, while your symptoms may not require aggressive treatment, they are certainly bothersome and warrant a comprehensive evaluation. A multidisciplinary approach involving a dermatologist for your skin concerns and an endocrinologist for your hormonal health may provide the best outcomes. It’s essential to address both the symptoms and any underlying conditions to achieve long-term relief and improve your overall well-being.

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