Blood Test Results: Concerns About Lymphocytes and Leukemia - Oncology

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Blood test


Hello Dr.
Hu, I would like to ask you about my blood test results.
My WBC is 4.43, Neutrophils segmented 27.0, Lymphocytes 56.0, Monocytes 9.0, Eosinophils 5.0, Basophils 0.0, and Atypical lymphocytes 3.0.
In August of this year, I also had a WBC test done at my family medicine clinic, which showed WBC 5.42, Neutrophils segmented 26.0, Lymphocytes 64.0, Monocytes 1.0, Eosinophils 5.0, Basophils 0.0, and Atypical lymphocytes 4.0.
That same day, I was referred to a hematologist and had another blood draw because I had just recovered from a cold a little over a week prior.
The results were WBC 4.42, Neutrophils segmented 33.7, Lymphocytes 57.0, ESR 13 mm/hr, and CRP 0.023 mg/dL.
However, I am unsure if I had a cold during this blood draw as a few days later, I visited an ENT specialist due to some yellowish phlegm.
The doctor today mentioned that it seems I had a cold at the time of my first blood draw, which could indicate a viral infection, and reassured me that it is not leukemia.
He advised me to relax and that there is nothing to worry about, but he did not ask me to have another blood test immediately and suggested I return for follow-up in three months.
However, I am still concerned about the possibility of leukemia or other serious conditions, as atypical lymphocytes sound concerning.
I would like to know your opinion on this matter, so I hope you can help explain it to me.
Thank you!

H, 20~29 year old female. Ask Date: 2020/11/09

Dr. Hu Ziren reply Oncology


Atypical lymphocytes are a transient physiological response caused by viral infections and are not malignant.
Therefore, it is recommended to wait until the cold has resolved or to have blood drawn for follow-up after three months.

Reply Date: 2020/11/09

More Info


Understanding blood test results can be quite daunting, especially when it comes to interpreting specific values related to white blood cells (WBC), lymphocytes, and the potential implications for conditions like leukemia. Based on the data you've provided, let's break down the key components of your blood test results and address your concerns.


Key Components of Your Blood Test
1. WBC (White Blood Cell Count): Your WBC count is within the normal range (4.43), which typically falls between 4.0 and 11.0 x 10^9/L. This suggests that your immune system is functioning adequately, as WBCs are crucial for fighting infections.

2. Neutrophils (Neut.seg): Your neutrophil count is on the lower side (27.0), which can be concerning if it drops significantly below the normal range (usually around 40-75%). Neutrophils are the first line of defense against infections, particularly bacterial ones. A low count could indicate a higher susceptibility to infections.

3. Lymphocytes (Lympho): Your lymphocyte count is elevated (56.0), which can occur in response to viral infections or other inflammatory processes. Lymphocytes play a vital role in the immune response, particularly in fighting viral infections.

4. Monocytes (Mono): Your monocyte count (9.0) is also within the normal range. Monocytes are involved in the immune response and can increase during chronic infections or inflammatory conditions.

5. Eosinophils (Eos): Your eosinophil count (5.0) is slightly elevated, which can be associated with allergic reactions, parasitic infections, or certain autoimmune diseases.

6. Atypical Lymphocytes (A.lym): The presence of atypical lymphocytes (3.0) can be indicative of a viral infection or other immune responses. While the term "atypical" may sound alarming, it does not automatically suggest leukemia. Atypical lymphocytes can appear in various benign conditions, particularly viral infections.


Concerns About Leukemia
Your concern about leukemia is understandable, especially given the presence of atypical lymphocytes and fluctuations in your lymphocyte count. However, several factors can help alleviate these worries:
- Normal WBC Count: A normal WBC count is a reassuring sign. In leukemia, you would typically see elevated WBC counts, often accompanied by an abnormal distribution of cell types.

- Clinical Context: Your recent history of viral infections (e.g., cold symptoms) can explain the variations in your lymphocyte and neutrophil counts. Viral infections often lead to a relative increase in lymphocytes and a decrease in neutrophils.

- Follow-Up Recommendations: Your healthcare provider's recommendation to follow up in three months is standard practice. This allows for monitoring any changes over time, especially after your recent viral infection.


Conclusion
In summary, while your blood test results show some variations, they do not strongly indicate leukemia, especially given the normal WBC count and the context of recent viral infections. The presence of atypical lymphocytes can be associated with benign conditions, particularly in the context of an ongoing infection. It is essential to maintain open communication with your healthcare provider, who can provide personalized advice based on your overall health and any symptoms you may experience.

If you continue to feel anxious about your health, consider discussing your concerns with your doctor, who may recommend further testing or a referral to a hematologist for additional reassurance. Remember, understanding your health is a journey, and it's okay to seek clarity along the way.

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