Vascular Permeability Issues in Varicose Veins - Cardiology

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Vascular wall permeability issues


Hello, doctor.
I was previously diagnosed with varicose veins at stages II to III, with pigmentation present.
However, I am uncertain whether the following situation is related to vascular permeability issues.
Whenever I walk for a while, my calves exhibit signs of suspected vascular leakage, accompanied by a sensation of swelling.
There are large red patches on the skin surface over the areas of varicosity, which disappear after a short rest.
I am wondering if I should undergo additional tests regarding vascular permeability to facilitate treatment.
Thank you!

Xiao Lin, 60~69 year old female. Ask Date: 2020/12/09

Dr. Li Han reply Cardiology


Hello, regarding the inquiry "previously diagnosed with venous insufficiency stage II to III, with pigmentation," the described skin manifestations, such as the appearance of suspected vascular leakage in the calves after prolonged walking, accompanied by a sensation of swelling and large red patches on the skin surface over the areas of venous insufficiency that disappear after a short rest, seem less related to vascular permeability issues.
Instead, they are more associated with congestion and dilation of microvessels, such as changes in skin erythema.
It is still advisable to consult a dermatologist for further evaluation.
The Changhua Hospital of the Ministry of Health and Welfare is concerned about your health.

Reply Date: 2020/12/09

More Info


Understanding vascular permeability issues in the context of varicose veins is crucial for managing symptoms and preventing complications. Varicose veins, which are characterized by swollen, twisted veins often visible just under the surface of the skin, can lead to a variety of symptoms, including pain, swelling, and skin changes. The underlying mechanism often involves increased venous pressure, which can affect the permeability of the blood vessels.

When you mention experiencing symptoms such as swelling and the appearance of red patches on the skin after prolonged walking, it suggests that there may be an issue with venous return and possibly increased vascular permeability in the affected areas. This can lead to the leakage of fluid and proteins from the blood vessels into the surrounding tissues, causing edema (swelling) and skin discoloration.

In varicose veins, the valves within the veins may become incompetent, meaning they do not close properly. This incompetence allows blood to flow backward, increasing pressure in the veins and leading to the symptoms you describe. The increased pressure can cause the walls of the veins to stretch and become more permeable, resulting in the leakage of blood components into the surrounding tissues, which may explain the red patches and swelling you observe.

The transient nature of your symptoms—where the redness and swelling subside with rest—indicates that the issue may be related to venous stasis, where blood pools in the veins due to prolonged standing or walking. This pooling can exacerbate the permeability issues, leading to the symptoms you experience.

To address your concerns about vascular permeability and whether further testing is necessary, it may be beneficial to consult with a vascular specialist. They can perform a thorough evaluation, which may include Doppler ultrasound studies to assess blood flow and valve function in the veins. These tests can help determine the extent of venous insufficiency and whether there are any significant issues with vascular permeability.

In terms of treatment, managing varicose veins often involves lifestyle modifications such as elevating the legs, wearing compression stockings, and engaging in regular physical activity to improve venous return. In some cases, medical interventions such as sclerotherapy or laser treatments may be recommended to close off the affected veins and improve symptoms.

If vascular permeability issues are confirmed, additional treatments may be considered to address the underlying causes. This could include medications to improve circulation or reduce inflammation, as well as more advanced procedures to correct venous insufficiency.

In summary, your symptoms of swelling and skin changes after prolonged walking may indeed be related to vascular permeability issues associated with varicose veins. Consulting with a vascular specialist for further evaluation and potential testing is advisable to determine the best course of action for your condition. Early intervention can help prevent complications and improve your quality of life.

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