Medication-Induced Sexual Dysfunction: A Psychiatric Perspective - Psychiatry

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Hello doctor...
Due to my personality being prone to tension and anxiety, I have developed acid reflux and gastritis.
In mid-August, my doctor prescribed me Eslapion (癒利舒盼錠) to take one tablet before bedtime.
Since I started taking it, I initially experienced a complete lack of sensation and libido during sexual activity, and later developed erectile dysfunction, where I would become erect but then immediately lose my erection, making it impossible to engage in sexual intercourse.
Could this be caused by the medication? Please advise.
Thank you.

Niming, 40~49 year old female. Ask Date: 2020/12/30

Dr. Lin Mianzhang reply Psychiatry


Hello: Generally, Eulexin (flutamide) does not cause decreased libido or erectile dysfunction.
However, if you are concerned that this medication may be the cause, you can try discontinuing it to see if the symptoms persist.
If the symptoms resolve after stopping the medication, you can discuss with your physician the possibility of switching to a different medication.
Wishing you a speedy recovery.

Reply Date: 2020/12/30

More Info


Medication-induced sexual dysfunction is a significant concern for many patients, particularly those taking psychiatric medications. In your case, it appears that you have been prescribed a medication known as "Lurasidone" (癒利舒盼錠), which is an atypical antipsychotic often used to treat conditions such as anxiety and depression. One of the well-documented side effects of this class of medications is sexual dysfunction, which can manifest as reduced libido, erectile dysfunction, and difficulties in achieving orgasm.

The mechanism behind medication-induced sexual dysfunction is multifaceted. Atypical antipsychotics like Lurasidone can alter neurotransmitter levels in the brain, particularly serotonin and dopamine. While these medications can be effective in managing anxiety and mood disorders, they can also inhibit sexual arousal and performance. For instance, increased serotonin levels can dampen sexual desire and responsiveness, leading to a lack of sexual pleasure and difficulties in achieving or maintaining an erection.

In your situation, the timeline of your symptoms correlates with the initiation of the medication. The onset of complete loss of sexual desire and subsequent erectile dysfunction shortly after starting Lurasidone strongly suggests that the medication is indeed a contributing factor. It is important to note that sexual side effects can vary widely among individuals, and not everyone will experience them to the same degree.

If you are experiencing these side effects, it is crucial to communicate openly with your prescribing physician. They can assess the severity of your symptoms and consider several options for management. These may include:
1. Medication Adjustment: Your doctor may suggest adjusting the dosage of Lurasidone or switching to a different medication that has a lower risk of sexual side effects. There are alternative treatments available that may not impact sexual function as significantly.

2. Add-on Medications: In some cases, doctors may prescribe additional medications to counteract the sexual side effects. For example, medications like sildenafil (Viagra) or tadalafil (Cialis) can help with erectile dysfunction.

3. Therapeutic Interventions: Engaging in therapy, such as cognitive-behavioral therapy (CBT), can help address anxiety and stress related to sexual performance, which may also alleviate some of the dysfunction.

4. Lifestyle Modifications: Incorporating lifestyle changes such as regular exercise, a healthy diet, and stress management techniques can improve overall well-being and may help mitigate some of the side effects.

5. Monitoring and Follow-up: Regular follow-up appointments with your healthcare provider are essential to monitor your symptoms and make necessary adjustments to your treatment plan.

It is also worth noting that while some sexual side effects may improve after discontinuation of the medication, others may persist. The duration of these effects can vary based on individual physiology and the specific medication involved. Therefore, it is vital to have an ongoing dialogue with your healthcare provider to ensure that your treatment plan aligns with your overall health goals, including sexual health.

In conclusion, it is highly likely that the sexual dysfunction you are experiencing is related to the medication you are taking. Do not hesitate to reach out to your doctor to discuss your symptoms and explore potential solutions. Your sexual health is an important aspect of your overall well-being, and there are options available to help you regain your sexual function and satisfaction.

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