Antibiotic Side Effects: Diarrhea and Skin Rashes - Gastroenterology and Hepatology

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Diarrhea after taking antibiotics?


Hello, doctor.
Recently, I had sinusitis and took antibiotics for almost three weeks.
My sinusitis has improved, and after finishing the antibiotics, I didn't go back to see the doctor.
However, it's been almost a week since I stopped the antibiotics, and I've been experiencing diarrhea several times a day.
I also have developed rashes on my skin.
Could this be a side effect of the antibiotics?

Skyy, 30~39 year old female. Ask Date: 2021/04/22

Dr. Yang Zhichao reply Gastroenterology and Hepatology


Hello Mr.
Skyy, the use of antibiotics can also lead to diarrhea, primarily due to changes in the balance of gut bacteria or the effects of certain medications.
As for the skin itching, it may be due to an allergy or other factors.
You may want to consult a physician for further evaluation.
Thank you for your question.

Reply Date: 2021/04/22

More Info


Hello! It sounds like you are experiencing some troubling side effects after your course of antibiotics for sinusitis. Let's break down your concerns regarding diarrhea and skin rashes, which can indeed be related to antibiotic use.

Antibiotics are powerful medications used to treat bacterial infections, but they can also disrupt the natural balance of bacteria in your body, particularly in your gut. This disruption can lead to a condition known as antibiotic-associated diarrhea (AAD). When antibiotics kill off the harmful bacteria causing an infection, they can also unintentionally kill beneficial bacteria that help maintain a healthy digestive system. This imbalance can result in diarrhea, which may occur during or after the course of antibiotics.

In your case, since you mentioned that you completed your antibiotic treatment nearly a week ago but are still experiencing diarrhea, it is possible that the antibiotics have altered your gut flora, leading to persistent gastrointestinal symptoms. The most common bacteria associated with AAD is Clostridium difficile (C. diff), which can cause severe diarrhea and is often a concern after antibiotic use. If your diarrhea is severe, persistent, or accompanied by other symptoms such as fever or abdominal pain, it is crucial to consult your healthcare provider for further evaluation.

As for the skin rashes you are experiencing, antibiotics can also lead to allergic reactions in some individuals. Skin rashes can manifest in various forms, including hives, rashes, or even more severe reactions like Stevens-Johnson syndrome, although the latter is rare. If the rash is itchy, spreading, or accompanied by other symptoms such as difficulty breathing or swelling of the face or throat, you should seek medical attention immediately, as these could be signs of a serious allergic reaction.

In summary, both diarrhea and skin rashes can indeed be side effects of antibiotic use. It is essential to monitor your symptoms closely. If your diarrhea persists or worsens, or if you develop any concerning symptoms related to the rash, please reach out to your healthcare provider for guidance. They may recommend specific treatments, such as probiotics to help restore gut flora or antihistamines for allergic reactions, depending on your symptoms.

Additionally, it’s worth noting that maintaining a healthy diet, staying hydrated, and possibly incorporating probiotics (after consulting your doctor) can help support your recovery from these side effects. Always communicate openly with your healthcare provider about any side effects you experience during or after antibiotic treatment, as they can provide tailored advice and support for your situation.

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