Long-Term Use of Ovulation Drugs: Effects on Fertility and Health - Obstetrics and Gynecology

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Is there any relationship with long-term use of ovulation medications?


Hello, doctor.
I have been using ovulation medications for the past two months in hopes of successfully conceiving.
I would like to know the following:
1.
I read online that ovulation medications can cause thinning of the endometrium.
If I continue to take these medications without becoming pregnant, could it make it more difficult to conceive later on? If I want to continue taking ovulation medications to increase my chances of conception and to determine the timing for conception, how should I use them correctly?
2.
Although I understand that menstruation typically does not occur during pregnancy, could it be possible that one of the eggs has successfully been fertilized while the others that were not fertilized are expelled, resulting in a situation where I am pregnant but still experience menstruation?
3.
I read that one of the factors contributing to difficulty in conceiving is blocked fallopian tubes.
Is a hysterosalpingography (HSG) covered by health insurance or is it out-of-pocket? If it is out-of-pocket, what is the approximate cost?
Thank you for your answers.
🙏

Niming, 30~39 year old female. Ask Date: 2021/04/22

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, taking ovulation medications can cause a thinner endometrium.
It is possible to combine them with estrogen to increase the thickness.
Ovulation typically occurs around 15 days before menstruation.
Generally, an ultrasound is performed in the outpatient clinic to check the size of the follicles and determine the timing of ovulation.
If menstruation occurs, it indicates that pregnancy has not happened.
A hysterosalpingography (HSG) is available, which costs over 1,000 NT dollars, and the fees may vary by hospital.
Wishing you good health.

Reply Date: 2021/04/22

More Info


When considering the long-term use of ovulation drugs and their effects on fertility and health, it's essential to understand both the physiological implications and the proper usage of these medications.
1. Impact on Endometrial Thickness and Fertility: It is true that certain ovulation-inducing medications, particularly those that stimulate the ovaries, can lead to a thinner endometrial lining. This is a concern because a healthy endometrial lining is crucial for implantation of a fertilized egg. If you are using ovulation drugs continuously without achieving pregnancy, there is a possibility that the endometrial lining may not be optimal for implantation in future cycles. Therefore, it is advisable to have regular monitoring by a healthcare provider, who can assess the thickness of the endometrium through ultrasound and adjust your treatment plan accordingly. If you are considering using ovulation drugs to increase your chances of conception, it is essential to follow a prescribed regimen and have regular check-ups to monitor your body's response.

2. Menstruation During Early Pregnancy: It is uncommon but possible to experience bleeding during early pregnancy, which can sometimes be mistaken for a menstrual period. If you are taking ovulation drugs that stimulate the production of multiple eggs, it is conceivable that one egg could be fertilized while others are not. In such cases, the body may still shed the unfertilized eggs, leading to bleeding. However, if you suspect you might be pregnant, it is crucial to take a pregnancy test rather than relying on the presence or absence of menstruation as an indicator of pregnancy. If you experience unusual bleeding or have concerns about your menstrual cycle while on ovulation drugs, consult your healthcare provider for further evaluation.

3. Hysterosalpingography (HSG) and Tubal Blockage: Hysterosalpingography is a procedure used to examine the condition of the fallopian tubes and the uterine cavity. It can help identify any blockages that might be contributing to infertility. In many healthcare systems, this procedure may not be covered by insurance and could be considered a self-pay service. The cost can vary widely depending on the facility and location, but it typically ranges from $300 to $1,000. It is advisable to check with your healthcare provider and your insurance company to understand the coverage options available to you.

In summary, while ovulation drugs can be beneficial for enhancing fertility, their long-term use requires careful management to avoid potential complications such as a thin endometrial lining. Regular monitoring and communication with your healthcare provider are essential to ensure that you are using these medications effectively and safely. If you have concerns about your menstrual cycle, potential pregnancy, or the need for further diagnostic procedures like HSG, do not hesitate to reach out to your healthcare provider for personalized advice and support.

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