PCOS: Effects of Medications on Menstrual Cycle and Fertility - Obstetrics and Gynecology

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Polycystic Ovary Syndrome (PCOS)


Blood tests confirmed polycystic ovary syndrome (PCOS) and elevated androgen levels (testosterone at 59.50), along with mild hypothyroidism (the endocrinologist mentioned that medication is not yet necessary).
My gynecologist prescribed oral metformin and spironolactone.
What are the long-term effects of taking these medications? Although I had a successful menstrual period this time due to the medication, this does not necessarily indicate ovulation, correct? If I want to conceive, is the likelihood very low?

Tina, 20~29 year old female. Ask Date: 2019/09/26

Dr. Huang Jianzhong reply Obstetrics and Gynecology


Blood tests confirmed polycystic ovary syndrome (PCOS) and elevated androgen levels (testosterone at 59.50), along with mild hypothyroidism (the endocrinologist stated that medication is not yet necessary).
I have irregular menstrual cycles, and my gynecologist prescribed oral metformin and clomiphene citrate.
What are the long-term effects of taking these medications?
Answer: It is safe to take these medications; I was able to have a regular menstrual cycle this time, but this does not necessarily indicate ovulation, correct?
Answer: It indicates that ovulation may occur, but the chances of conception are still low, right?
Answer: The chances of conception with treatment will not be very low.

Reply Date: 2019/09/26

More Info


Polycystic Ovary Syndrome (PCOS) is a complex hormonal disorder that affects many women of reproductive age. It is characterized by a combination of symptoms, including irregular menstrual cycles, excess androgen levels (such as elevated testosterone), and polycystic ovaries. In your case, you have been diagnosed with PCOS and have elevated testosterone levels, which can contribute to various symptoms such as hirsutism (excess hair growth), acne, and weight gain. Additionally, you mentioned having hypothyroidism, which can further complicate the management of PCOS.

The medications you are taking, which include oral contraceptives (like the ones you referred to as "伏糖膜衣錠" and "使洛利通錠"), are often prescribed to help regulate menstrual cycles and manage symptoms associated with PCOS. These medications work primarily by providing a steady dose of hormones that can help to balance the hormonal fluctuations that occur in PCOS. They can also help to reduce the levels of androgens, thereby alleviating symptoms such as acne and hirsutism.

It is important to note that while these medications can help induce a menstrual cycle, they do not guarantee ovulation. In many cases, women with PCOS may experience regular menstrual cycles while still not ovulating regularly. This is a crucial point to consider if you are trying to conceive. The presence of a menstrual period does not necessarily indicate that ovulation has occurred, which is essential for pregnancy.

If you are considering pregnancy, it is advisable to discuss your situation with your healthcare provider. They may recommend additional treatments to promote ovulation, such as Clomiphene citrate or letrozole, which are often used to stimulate ovulation in women with PCOS. Lifestyle modifications, including weight management through diet and exercise, can also significantly improve ovulatory function and overall fertility in women with PCOS.

Regarding the long-term use of oral contraceptives, they are generally considered safe for many women. However, it is essential to have regular follow-ups with your healthcare provider to monitor any potential side effects and to evaluate the effectiveness of the treatment. Some women may experience side effects such as mood changes, weight gain, or increased risk of blood clots, especially if they have other risk factors.

In summary, while the medications you are taking can help regulate your menstrual cycle, they do not ensure ovulation. If you are planning to conceive, it is crucial to work closely with your healthcare provider to explore options that can enhance your chances of ovulation and pregnancy. Additionally, managing your overall health, including thyroid function and metabolic factors, will be vital in your journey toward conception.

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