Severe Abdominal Pain and Reactions After Cytotec: What to Do Next? - Obstetrics and Gynecology

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Shivering, chills, and severe abdominal pain?


I have anemia caused by uterine fibroids, and my doctor arranged for the placement of a Mirena IUD for bleeding control.
Three days before the Mirena insertion, I started using CYTOTEC vaginally.
After the first insertion, I experienced a full-body rash, shaking, chills, and severe abdominal pain, which was very uncomfortable.
I don't have the courage to insert it a second time.
Should I continue using CYTOTEC? Can I proceed with the Mirena insertion without using CYTOTEC? Thank you.

pappy, 40~49 year old female. Ask Date: 2021/04/27

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it might be related to the use of the suppository.
If you are feeling very uncomfortable, it is advisable not to use it.
I recommend returning to your gynecologist to check if you can have an intrauterine device (IUD) inserted.
Wishing you good health.

Reply Date: 2021/04/27

More Info


When dealing with severe abdominal pain and adverse reactions after using Cytotec (misoprostol), it is crucial to prioritize your health and safety. Cytotec is often used for various medical purposes, including inducing labor, managing miscarriage, and treating ulcers. However, it can cause side effects, including abdominal pain, diarrhea, nausea, and in some cases, allergic reactions such as rashes and chills.

Given your experience of severe abdominal pain, rash, shivering, and cold sensations after the first dose of Cytotec, it is essential to consult your healthcare provider before proceeding with any further doses. These symptoms may indicate an adverse reaction to the medication, and continuing to use it could exacerbate your condition or lead to more severe complications.

Here are some steps you should consider:
1. Consult Your Doctor: Immediately reach out to the healthcare provider who prescribed Cytotec. Inform them about the reactions you experienced, including the severity of your abdominal pain and any other symptoms. They may recommend stopping the medication altogether or suggest alternative treatments.

2. Alternative Treatments: If Cytotec is not suitable for you due to the adverse reactions, your doctor may consider other options for managing your condition. For instance, if the goal is to manage heavy bleeding or treat fibroids, there are other medications and procedures available that may be safer for you.

3. Monitoring Symptoms: Keep a close watch on your symptoms. If you experience worsening abdominal pain, fever, or any new symptoms, seek medical attention immediately. These could be signs of a more serious condition that requires prompt intervention.

4. Discuss the Use of Mirena: If you are considering the Mirena IUD for managing heavy menstrual bleeding or as a contraceptive method, discuss this option with your doctor. They can provide guidance on whether it can be inserted without the need for Cytotec, especially given your recent adverse reactions.

5. Pain Management: In the meantime, if you are experiencing significant pain, discuss safe pain management options with your healthcare provider. They may recommend over-the-counter pain relievers or other medications that are compatible with your current health status.

6. Follow-Up Care: Ensure you have a follow-up appointment scheduled with your healthcare provider to monitor your condition and discuss the next steps in your treatment plan.

In summary, do not proceed with further doses of Cytotec without consulting your healthcare provider, especially after experiencing severe reactions. Your health and safety should always come first, and there are alternative treatments available that may be more suitable for your situation. Always communicate openly with your healthcare team about any concerns or side effects you experience during treatment.

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