Mediterranean Anemia: Key Blood Test Indicators - Internal Medicine

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Mediterranean anemia (also known as thalassemia)


Hello doctor, I received my military service medical examination report.
The white blood cell count (WBC) is 6.6 x 10^3/µL, red blood cell count (RBC) is 6.51 x 10^6/µL, hemoglobin (Hb) is 13.4 g/dL, hematocrit (Hct) is 43.0%, and mean corpuscular volume (MCV) is 65.9 fL.
Is there a high possibility of having thalassemia?

Cai Xiansheng, 10~19 year old female. Ask Date: 2021/05/25

Dr. Hong Yuanbin reply Internal Medicine


Hello, it is indeed possible, but Mediterranean anemia can only be confirmed through further testing.
Thank you for your inquiry.

Reply Date: 2021/05/25

More Info


Mediterranean anemia, commonly known as thalassemia, is a genetic blood disorder characterized by the body’s inability to produce adequate hemoglobin, which is essential for transporting oxygen in the blood. The condition is prevalent in individuals of Mediterranean descent, but it can also affect people from other regions. To understand the likelihood of having Mediterranean anemia based on your blood test results, we need to analyze the key indicators you provided.

1. White Blood Cell Count (WBC): Your WBC count is 6.6 x 1000/µL, which falls within the normal range (approximately 4.5 to 11.0 x 1000/µL). This indicates that your immune system is functioning well and does not suggest any immediate issues related to anemia.

2. Red Blood Cell Count (RBC): Your RBC count is 6.51 x 10^6/µL, which is higher than the normal range for adult males (approximately 4.7 to 6.1 x 10^6/µL) and for females (approximately 4.2 to 5.4 x 10^6/µL). A high RBC count can sometimes be seen in conditions where the body is compensating for low hemoglobin levels, which is common in thalassemia.

3. Hemoglobin (Hb): Your hemoglobin level is 13.4 g/dL, which is within the normal range for adult males (13.5 to 17.5 g/dL) and slightly low for females (12.0 to 15.5 g/dL). While this level does not indicate anemia, it is essential to consider it in conjunction with other parameters.

4. Hematocrit (Hct): Your hematocrit level is 43.0%, which is also within the normal range (approximately 38.3% to 48.6% for males and 35.5% to 44.9% for females). This suggests that the proportion of blood volume occupied by red blood cells is normal.

5. Mean Corpuscular Volume (MCV): Your MCV is 65.9 fL, which is significantly lower than the normal range (approximately 80 to 100 fL). A low MCV indicates microcytic anemia, which is often associated with thalassemia and iron deficiency anemia. In thalassemia, the red blood cells are smaller than normal due to the impaired production of hemoglobin.

Based on these indicators, particularly the low MCV and elevated RBC count, there is a possibility of Mediterranean anemia (thalassemia). However, it is crucial to note that a definitive diagnosis cannot be made solely based on these blood test results. Additional tests, such as hemoglobin electrophoresis, are necessary to determine the specific type of hemoglobin present and to confirm the diagnosis of thalassemia.

In summary, while your blood test results suggest a potential for Mediterranean anemia due to the low MCV and elevated RBC count, it is essential to consult with a healthcare provider or a hematologist for further evaluation and testing. They can provide a comprehensive assessment and guide you through the necessary steps for diagnosis and management. Early detection and appropriate management are vital in addressing any complications associated with thalassemia, ensuring a better quality of life.

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Understanding Mediterranean Anemia: Key Lab Values and Implications

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Dr. Lin Shunfa reply Internal Medicine
To Rose: Based on the test data, there may sometimes be errors in the computer input. HGB 13.2: no anemia. MCV 77.2: microcytic, MCH 25.1: low. Iron 24: low iron, low TIBC, low ferritin. RDW-CV 19.7: elevated. If anemia is present, the likelihood of iron deficiency anemia is the ...

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Hello, doctor. I have had anemia issues since childhood and have been informed by various laboratory technicians that I may have thalassemia. Below are the results from my last two tests. I am unsure if these results can help in making a diagnosis. Additionally, I would like to k...


Dr. Hu Ziren reply Oncology
This data may indicate thalassemia and iron deficiency anemia, and further testing is needed for differential diagnosis. However, if there is a family history of thalassemia, the likelihood of hereditary thalassemia is higher. If thalassemia is confirmed, oral folic acid can be a...

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Can This Blood Test Indicate Mediterranean Anemia?

RBC: 5.77 x 10^6/uL WBC: 5.57 x 10^3/uL Hb: 13.9 g/dL Hct: 42.5% PLT: 271 x 10^3/uL MCV: 73.7 fL MCH: 24.1 pg MCHC: 32.7 g/dL HbH: Negative HbA2: 2.1% HbA1: 97.9% RDW: 33.8% HbF: <0.5% Ferritin: 38.56 ng/mL TIBC: 395 µg/dL Serum Iron: 64 µg/dL ...


Dr. Li Shengkai reply Cardiology
According to the blood test report you provided, the levels do not indicate anemia; however, the red blood cells are smaller than normal, and since there is no iron deficiency in the body, it raises the suspicion of being a carrier of thalassemia.

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Hello Doctor: This is my boyfriend's blood test report: WBC 4.57, RBC 5.95, HGB 10.5, Ht 36.4, MCV 61.2, MCH 17.6, MCHC 28.8, PLT 417. Does this indicate Mediterranean anemia?


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Hello: It could be either thalassemia or iron deficiency anemia, and further testing is needed to confirm. Thank you for your message!

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