Medication Interactions: Concerns with YOU-JET and Other Drugs - Psychiatry

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Questions related to the use of antidepressant medication?


From the end of February to mid-May of this year, I consistently took the following medications: at 7:30 AM, I took one 20 mg of Lichangning after breakfast; at 7:00 PM, I took one 10 mg of Ritalin; and at around 11:00 PM, I took half a 50 mg tablet of YOU-JET (anxiety relief) and one 10 mg tablet of a bronchodilator.
Due to the pandemic, I did not return for a follow-up appointment to refill my prescriptions, and from May 28 to June 15, I did not take the anxiety relief or bronchodilator medications.
During this period without medication, I did not experience any significant discomfort.
On June 15, due to severe nasal allergies, I visited a clinic to refill the bronchodilator and received an additional three days' supply of Yongxin Nasal Relief tablets to take at bedtime for allergy treatment.
After a follow-up appointment with the psychiatric department on June 16, I continued taking half a tablet of the anxiety relief medication at bedtime.
On June 17, I took half a tablet of the anxiety relief medication, a bronchodilator, and a nasal relief tablet in the evening, after which I experienced insomnia and increased heart rate.
On June 18, at 7:00 PM, I took Lichangning and then took half a tablet of the anxiety relief medication, a bronchodilator, and Yongxin Nasal Relief tablets before bed.
In the middle of the night, I experienced insomnia, increased heart rate, slight tremors in my hands and feet, headache, and nausea, which persisted until the daytime of June 19.
The symptoms would lessen during the day, but any recurrence of symptoms would still cause significant discomfort.
I would like to inquire whether the discomfort described above could be due to interactions between the medications.

Xiao Gan, 10~19 year old female. Ask Date: 2021/06/19

Dr. Yan Congyou reply Psychiatry


Hello, Xiao Gan: Based on the symptoms you described, it seems that the side effects may be due to the sudden resumption of medication after a period of not taking the antidepressant.
This type of selective serotonin reuptake inhibitor (SSRI) is recommended for long-term and stable use.
If you are considering reducing the dosage, it is best to discuss it with your physician.
Inconsistent medication frequency can lead to more frequent side effects, rather than interactions between medications.
SSRIs may cause discomfort during the first week of use, but this typically subsides as you adjust.
Additionally, it is not advisable to take Modafinil in the evening, as it may cause central nervous system stimulation, leading to the aforementioned symptoms.

Reply Date: 2021/06/19

More Info


Based on your detailed description of your medication regimen and the symptoms you experienced, it appears that you may be encountering some interactions between the medications you are taking, particularly with YOU-JET (Sertraline) and the other medications prescribed for your allergies and asthma.

Understanding the Medications:
1. YOU-JET (Sertraline): This is a selective serotonin reuptake inhibitor (SSRI) commonly used to treat depression and anxiety disorders. It works by increasing the levels of serotonin in the brain, which can help improve mood and reduce anxiety.

2. Asthma Medication (likely a bronchodilator): The medication you mentioned, which seems to be a bronchodilator, is used to relieve symptoms of asthma by relaxing the muscles of the airways.
3. Nasal Allergy Medication (永信鼻福錠): This medication is likely an antihistamine or a corticosteroid used to treat nasal allergy symptoms.

Potential Interactions:
- Sertraline and Bronchodilators: While there is no direct contraindication between SSRIs like Sertraline and bronchodilators, combining these medications can sometimes lead to increased side effects such as anxiety, restlessness, or insomnia, especially if the bronchodilator has stimulant effects.

- Sertraline and Antihistamines: Antihistamines can cause sedation, which may counteract some of the stimulating effects of Sertraline. However, if you are taking a non-sedating antihistamine, this may not be a significant concern.
- Cumulative Effects: The combination of multiple medications that can affect the central nervous system (CNS) may lead to increased side effects. For example, if both the asthma medication and the allergy medication have stimulant properties, they could exacerbate symptoms like increased heart rate, anxiety, or insomnia.

Symptoms Experienced:
The symptoms you described—insomnia, increased heart rate, tremors, headache, and nausea—could be attributed to several factors:
- Medication Interaction: The combination of medications may have led to an overstimulation of the CNS, resulting in anxiety-like symptoms.

- Withdrawal Effects: Since you had a period of not taking your medications, your body might have been adjusting to the absence of Sertraline, which can sometimes lead to withdrawal symptoms, including anxiety and physical discomfort.

- Allergic Reaction or Side Effects: It’s also possible that the nasal allergy medication could have side effects that contribute to your symptoms, especially if it contains ingredients that can cause jitteriness or increased heart rate.

Recommendations:
1. Consult Your Healthcare Provider: It is crucial to discuss your symptoms with your prescribing physician or a clinical pharmacist. They can review your medication regimen in detail and determine if any adjustments are necessary.

2. Monitor Your Symptoms: Keep a detailed log of your symptoms, including when they occur and their severity. This information can be invaluable for your healthcare provider.

3. Avoid Self-Medicating: While it may be tempting to adjust dosages or add over-the-counter medications, this can complicate your situation further. Always consult with a healthcare professional before making changes.

4. Consider Timing and Dosage: Sometimes, adjusting the timing of when you take your medications can help mitigate side effects. Your healthcare provider can assist with this.

5. Stay Informed: Understanding the potential interactions between your medications can empower you to manage your health better. Always ask questions and seek clarification from your healthcare team.

In summary, while it is possible that your symptoms are related to the interactions between the medications you are taking, a thorough evaluation by a healthcare professional is necessary to determine the exact cause and appropriate management. Your health and safety should always be the priority when dealing with multiple medications.

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