Medication Concerns During Pregnancy: What You Need to Know - Obstetrics and Gynecology

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I visited an ENT specialist due to a sensation of a foreign body in my throat.
The doctor suggested that my poor sleep might have caused gastroesophageal reflux and prescribed anti-anxiety medication (Yikening), as well as gastric protective tablets (Wei Ni Hao), cough relief (Mei Shu Ke), and enteric-coated tablets (Pu Yan Xi).
I informed the doctor that I am trying to conceive, and on that day, June 10, it was the first day of my menstrual period.
The doctor mentioned that it was fine to take the medications but advised to stop before ovulation.
However, I was still quite worried, so I took one dose of the medication before bed that night and did not continue.
My ovulation period was from June 19 to June 25, and I have now confirmed that I am pregnant.
Will these medications affect the fetus? When I discovered my pregnancy, I consulted with an obstetrician about this concern, and the doctor said that the medications would have been metabolized by the time I conceived, so there is no need to worry.
However, I still feel anxious, so I would like to ask for your advice.
Thank you.

Kate, 30~39 year old female. Ask Date: 2021/07/13

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, please follow the doctor's instructions.
Wishing you good health.

Reply Date: 2021/07/13

More Info


When it comes to medication use during pregnancy, it is essential to approach the topic with caution and a thorough understanding of the potential risks and benefits. The safety of medications during pregnancy is classified by the FDA into five categories: A, B, C, D, and X. Each category reflects the level of risk associated with the use of a particular medication during pregnancy.

1. Category A: These medications have been tested in pregnant women and have shown no risk to the fetus in the first trimester. Examples include certain vitamins and minerals.

2. Category B: These medications have not been shown to cause harm to the fetus in animal studies, but there are no well-controlled studies in pregnant women. Examples include amoxicillin and certain antihistamines.

3. Category C: These medications have shown adverse effects on the fetus in animal studies, but there are no adequate studies in humans. Medications in this category should only be used if the potential benefits justify the potential risks.

4. Category D: There is evidence of human fetal risk, but the benefits of using the medication may outweigh the risks in certain situations.

5. Category X: These medications are contraindicated in pregnancy due to evidence of fetal abnormalities.

In your case, you mentioned that you were prescribed medications such as anxiety medication (likely a benzodiazepine) and medications for gastrointestinal issues. It is crucial to know the specific medications you were prescribed, as their safety profiles can vary significantly.

Given that you were in the early stages of your menstrual cycle when you took the medications, and considering that your doctor indicated that the medications would be metabolized by the time you conceived, the risk of teratogenic effects (birth defects) is likely minimal. However, it is understandable to feel anxious about the potential effects of any medication taken prior to pregnancy.

The medications you mentioned, such as "益可寧" (likely a form of anxiolytic) and "美舒咳" (a cough medication), should be evaluated based on their specific classifications. If they fall into Category B or C, the risks may be manageable, especially if taken in small doses and for a short duration.
It is also important to consider that many women unknowingly take medications before realizing they are pregnant, and most pregnancies result in healthy babies despite this. The critical period for fetal development is during the first trimester, particularly the first 12 weeks, when the organs are forming. If you stopped taking the medications after realizing you were pregnant, this further reduces any potential risks.

If you are still feeling anxious, it would be beneficial to have an open discussion with your obstetrician or a maternal-fetal medicine specialist. They can provide you with personalized advice based on your medical history, the specific medications involved, and the current state of your pregnancy. Additionally, they may suggest non-pharmacological approaches to managing anxiety, such as cognitive-behavioral therapy or mindfulness techniques, which can be effective and safe during pregnancy.

In summary, while it is natural to be concerned about medication use during pregnancy, understanding the classifications and discussing your specific situation with a healthcare provider can help alleviate fears and ensure the best outcomes for both you and your baby.

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