Concerns About Taking Lansoprazole Capsules: Safety and Risks Explained - Gastroenterology and Hepatology

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Capsule issues?


Hello, doctor.
I have gastroesophageal reflux disease, and my doctor prescribed Lansoprazole for me.
However, yesterday the capsule accidentally fell on the floor, and due to concerns about the recent pandemic, I was afraid the capsule might be contaminated with viruses, so I opened the capsule and took the powder inside instead.
Later, I found out that some capsules should not be opened.
Will this cause any damage to my esophagus or respiratory tract? After taking it, I felt something unusual in my throat...
Can medications for treating gastroesophageal reflux cause drug-induced esophagitis? I'm a bit worried.
Thank you, doctor.

A Wei, 20~29 year old female. Ask Date: 2021/07/17

Dr. Chen Shidian reply Gastroenterology and Hepatology


It will not cause direct harm, but it may reduce the effectiveness of the medication.

Reply Date: 2021/07/17

More Info


Taking Lansoprazole capsules, especially when you have concerns about their safety and potential risks, is an important topic to address. Lansoprazole is a proton pump inhibitor (PPI) commonly prescribed for conditions like gastroesophageal reflux disease (GERD) and peptic ulcers. It works by reducing the amount of stomach acid produced, which can help alleviate symptoms associated with acid reflux.

Regarding your specific situation, it is understandable to be concerned about the safety of taking a capsule that has fallen on the floor, especially during a time when there are heightened concerns about viruses. However, it is important to note that the active ingredient in Lansoprazole is typically stable and effective when taken as directed. Opening the capsule and consuming the powder inside is not generally recommended for several reasons.

Firstly, the capsule is designed to protect the active ingredient from stomach acid and to ensure that it is released in the appropriate part of the digestive system. By opening the capsule, you may alter the way the medication is absorbed, potentially reducing its effectiveness. While it is unlikely to cause direct harm to your esophagus or respiratory tract, the powder could irritate your throat, which might explain the "weird" feeling you experienced after taking it. If you continue to feel discomfort, it would be wise to consult your healthcare provider.

As for the concern about drug-induced esophagitis, it is true that certain medications, including PPIs like Lansoprazole, can lead to esophageal irritation if not taken properly. This is particularly a risk if the medication is taken without sufficient water or if the patient has difficulty swallowing. Symptoms of drug-induced esophagitis can include pain when swallowing, chest pain, or a sensation of food getting stuck in the throat. If you experience any of these symptoms, it is crucial to seek medical attention.

In general, while Lansoprazole is considered safe for most individuals when used as prescribed, long-term use can be associated with certain risks. These may include an increased risk of gastrointestinal infections, nutrient malabsorption (such as magnesium and vitamin B12), and potential kidney issues. Therefore, it is essential to use this medication under the guidance of a healthcare professional and to have regular follow-ups to monitor your condition.

If you have ongoing concerns about the safety of your medication or if you experience any adverse effects, do not hesitate to reach out to your doctor. They can provide personalized advice based on your medical history and current health status. In the meantime, ensure that you take your medications as directed, and if you ever have doubts about the integrity of a medication, it is always best to consult with a healthcare provider before proceeding.

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