Does Vaccination Cause Lymph Node Swelling? Common Concerns Explained

Is lymphadenopathy common after vaccination?

Dear Dr.
Chen,
I hope you remember me.
A few years ago, I consulted you regarding my lymph nodes.
I have a few questions again:
1.
Three years ago, I noticed a lymph node on the left side of my clavicle.
I had a CT scan three years ago and an ultrasound two years ago, and the doctors said everything was normal.
Last Tuesday, I received the COVID-19 vaccine (Moderna), and I read an article before the vaccination stating that swelling of lymph nodes after vaccination is indeed a possibility.
Is this true?
2.
After receiving the vaccine last Tuesday, five days later, I felt pain in the armpit of my right arm where I received the shot.
My wife also experienced the same pain in her armpit on the same side.
Is this a normal reaction?
3.
The lymph node on the left side of my clavicle was measured at 0.8 cm during the ultrasound.
It has been two years, and recently I feel it has enlarged to about 1.2 cm, but it is still movable.
Is this related to the vaccine? Today marks the seventh day since my vaccination.
If there is a connection, how long does it usually take for the lymph node to decrease in size?
4.
Thank you for your compassion and patience.

You again, worried little Ke., 40~49 year old female. Ask Date: 2021/07/27

Dr. Chen Sirong reply Oncology

Hello, Xiao Ke / 41 years old / Male.

1.
Is it true that vaccination can cause lymphadenopathy?
A: It is possible! However, it does not occur in everyone, and the incidence is relatively low; otherwise, it would be reported frequently on television.
2.
I received the vaccine last Tuesday, and five days later, I felt pain in the armpit of the arm that was vaccinated.
My wife also experienced armpit pain on the same side after her vaccination.
Is this a normal reaction?
A: Yes, it is normal.
3.
I have a lymph node on the left side of my clavicle that was measured at 0.8 cm via ultrasound two years ago.
Recently, I feel it has enlarged to about 1.2 cm, but it is still movable.
Is this related to the vaccine? Today marks the seventh day since my vaccination.
If it is related, how long does it usually take for the lymph node to decrease in size?
A: It would be best to check again one month after receiving the second dose.

Wishing you good health,
Taoyuan Hospital, Chen Si-Rong.

Reply Date: 2021/07/27

More Info

Vaccination can indeed cause lymph node swelling, and this is a common and generally benign reaction. When you receive a vaccine, particularly one that stimulates an immune response, such as the mRNA vaccines for COVID-19 (like Moderna), your body activates its immune system to recognize and respond to the vaccine components. This immune response can lead to inflammation, which may cause nearby lymph nodes to swell as they filter out the vaccine components and produce immune cells.

1. Lymph Node Swelling Post-Vaccination: It is well-documented that vaccines can cause lymphadenopathy (swelling of the lymph nodes). This is particularly true for vaccines that contain live attenuated viruses or those that elicit a strong immune response. In your case, the swelling of the lymph nodes after receiving the Moderna vaccine is a normal reaction. It indicates that your immune system is responding appropriately to the vaccine. The swelling can occur in the axillary (armpit) lymph nodes on the side of the vaccination, which is what you and your wife are experiencing.

2. Pain in the Axillary Region: The pain you are feeling in your armpit on the side where you received the vaccine is also a common side effect. This discomfort is typically due to the inflammation of the lymph nodes and surrounding tissues as your body mounts an immune response. It is usually temporary and should resolve within a few days to a week.

3. Changes in Existing Lymph Nodes: Regarding the lymph node you have been monitoring on the left side of your clavicle, it is not uncommon for existing lymph nodes to change in size due to various factors, including vaccination. The increase from 0.8 cm to approximately 1.2 cm could be related to the immune response triggered by the vaccine, especially if the lymph node is still mobile and not hard or fixed in place. However, it is essential to continue monitoring this lymph node, especially since you have a history of lymphadenopathy. If the node continues to grow or if you experience other concerning symptoms (such as fever, night sweats, or unexplained weight loss), it would be prudent to consult your healthcare provider for further evaluation.

4. Duration of Swelling: Typically, lymph node swelling post-vaccination should subside within a few days to a couple of weeks. If the swelling persists beyond this timeframe or if you have any concerns about the size or characteristics of the lymph node, it would be advisable to seek medical advice. Your healthcare provider may recommend follow-up imaging or other tests to ensure that everything is progressing normally.

In summary, while lymph node swelling after vaccination is a common occurrence and usually not a cause for concern, it is essential to remain vigilant about any changes in your lymph nodes, especially given your medical history. Regular follow-ups with your healthcare provider can help ensure that any potential issues are addressed promptly. Thank you for your thoughtful questions, and I hope this information provides clarity and reassurance regarding your concerns.

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