Enlarged Neck Lymph Nodes: Concerns and Cancer Risks - Oncology

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Enlargement of cervical lymph nodes?


Hello, Doctor! My mother is 67 years old.
She lived in China for an extended period while caring for children and received the Sinopharm vaccine on June 24 of this year.
At the end of August, she discovered swollen lymph nodes above her clavicle during a self-examination and sought medical attention on August 25.
An ultrasound revealed multiple lymph nodes from the bilateral neck to the supraclavicular area, with clear borders and partial loss of the medullary pattern.
The left side showed a fuller shape, while the right supraclavicular node measured 18 x 9 mm, and the left neck node measured 13 x 6 mm, with a richer blood flow signal on the left side.

On September 25, she returned to the hospital for a follow-up, and the ultrasound showed multiple lymph nodes from the bilateral neck to the supraclavicular area again, with clear borders and partial loss of the medullary pattern.
The right supraclavicular node measured 11 x 6 mm, and the left neck node measured 18 x 10 mm, with a reduced blood flow signal on the left side.
Given the suspicion of enlargement of the left lymph nodes, she underwent a fine needle aspiration biopsy of the left neck node on September 28.
The report indicated the presence of lymphocytes, a small number of tissue cells, and very few atypical epithelial cells, with no malignant findings observed in the smear.
It suggested re-evaluation or further examination if necessary.
Visually, the lymph nodes have significantly decreased in size since then.
It is worth mentioning that during the period between the two ultrasound examinations (from August 25 to September 25), my mother experienced a single episode of generalized urticaria, which she had never had before.
She has heard that swollen lymph nodes on the left side are closely associated with cancer, which has caused her significant anxiety, and I am also very concerned.
Based on the information provided, could this be related to the administration of the Chinese vaccine, and can we reasonably rule out the possibility of cancer? Thank you!

Kuai Le Fei Zhu, 30~39 year old female. Ask Date: 2021/11/10

Dr. Hu Ziren reply Oncology


It may simply be localized lymphadenopathy caused by generalized urticaria, and since the fine needle aspiration biopsy of the lymph nodes did not reveal any cancer cells and the size of the lymph nodes has decreased, it is recommended to just observe.
As for whether it is related to the vaccine, it would be best to consult an infectious disease specialist for clarification.

Reply Date: 2021/11/10

More Info


Understanding enlarged neck lymph nodes can be a source of significant anxiety, especially when there is a concern about cancer. In your mother's case, the findings from the ultrasound and fine needle aspiration cytology (FNAC) provide important insights into her condition.

Firstly, it is essential to understand that lymph nodes can enlarge for various reasons, including infections, inflammatory conditions, and malignancies. The fact that your mother has experienced an episode of urticaria (hives) during the period of lymph node enlargement may suggest an underlying allergic or inflammatory response, which could also contribute to lymphadenopathy (enlarged lymph nodes).
The ultrasound findings indicate that there are multiple lymph nodes in the neck and supraclavicular region, with some showing a loss of the normal fatty hilum, which can be a sign of reactive changes. The dimensions of the lymph nodes, particularly the largest ones measuring 18x10 mm and 11x6 mm, are significant but not necessarily indicative of malignancy on their own. The presence of increased blood flow in some nodes can also be associated with reactive processes rather than cancer.

The FNAC results are particularly reassuring. The report indicates the presence of lymphocytes and a few atypical epithelial cells, but importantly, it states that there is no evidence of malignancy. This is a crucial finding, as it suggests that the lymph nodes are likely responding to a benign process, such as an infection or inflammation, rather than a malignant one. The recommendation for follow-up or further testing is standard practice in cases where atypical cells are present but do not meet the criteria for malignancy.

Regarding the concern about the Chinese vaccine, while vaccines can sometimes lead to temporary lymphadenopathy as part of the immune response, there is no established direct link between the inactivated vaccines and long-term lymph node enlargement or cancer. It is more likely that the lymph node enlargement is related to an immune response to an infection or other benign causes, especially given the recent history of urticaria.

In summary, based on the information provided, it seems reasonable to conclude that the likelihood of your mother having cancer is low, especially given the FNAC results. However, continued monitoring is advisable, as lymph nodes can change over time. It is essential to maintain open communication with her healthcare provider, who can offer personalized advice and reassurance based on her clinical history and the results of her examinations.

In conclusion, while it is natural to feel anxious about the possibility of cancer, the current evidence suggests that your mother's enlarged lymph nodes are more likely related to a benign process. Regular follow-up and monitoring will help ensure that any changes are promptly addressed. Encourage your mother to discuss her concerns with her healthcare provider, who can provide further reassurance and guidance.

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