Persistent Cough: Causes and Treatment Options - Pulmonology

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Coughing for a long time?


Hello, Doctor: I have been coughing since I caught a cold around October last year, and it lasted for more than a month.
I later visited a pulmonologist who performed an X-ray and pulmonary function tests.
Initially, I was prescribed cough suppressants and expectorants, but my cough did not improve.
Eventually, the doctor prescribed a dry powder inhaler, which provided significant relief immediately.
The doctor mentioned that I might have asthma.
I continued using the inhaler for the next 7 to 8 months, and my condition was well controlled.
However, last month, I suddenly started coughing again, and it has been almost a month now.
The doctor switched my medication to a bronchodilator, and I am on the second day of using it, but there hasn't been much improvement.
My family believes that my cough might be caused by gastroesophageal reflux disease (GERD).
Could you please advise what might be the underlying cause of my symptoms?

Han, 20~29 year old female. Ask Date: 2021/08/22

Dr. Yang Wenda reply Pulmonology


Hello Han: Based on previous improvements with the inhaler, the physician's diagnosis of asthma seems to be correct.
However, asthma patients can still experience acute exacerbations due to factors such as colds, exposure to allergens (like dust mites or pollen), significant temperature changes, or gastroesophageal reflux.
It is recommended to continue using the bronchodilator along with medications to suppress gastric acid, which should help improve the condition.
As for whether there is gastroesophageal reflux, an endoscopy is necessary for diagnosis.

Reply Date: 2021/08/22

More Info


Persistent cough can be a frustrating and debilitating condition, and understanding its underlying causes is essential for effective treatment. Based on your description, it seems that you have been dealing with a chronic cough that has persisted for several months, with a history of asthma and recent changes in your treatment regimen. Let’s break down the potential causes and treatment options for your situation.


Potential Causes of Persistent Cough
1. Asthma: Given your previous diagnosis of asthma and the improvement you experienced with the inhaled medication (likely a bronchodilator), it is possible that your cough is related to asthma. Asthma can cause airway inflammation and hyperreactivity, leading to coughing, especially at night or with exercise.
2. Gastroesophageal Reflux Disease (GERD): Your family’s suggestion that your cough may be due to gastroesophageal reflux is also valid. GERD can cause acid to irritate the esophagus and throat, leading to a chronic cough. This is often worse at night or after meals, and it may be accompanied by symptoms such as heartburn or a sour taste in the mouth.

3. Postnasal Drip: Chronic sinusitis or allergies can lead to postnasal drip, where mucus drips down the back of the throat, triggering a cough. This is often worse at night and can be associated with nasal congestion or sinus pressure.

4. Chronic Bronchitis: If you have a history of smoking or exposure to irritants, chronic bronchitis could be a consideration. This condition is characterized by a persistent cough with mucus production.

5. Infections: Although less likely after several months, lingering infections such as bronchitis or pneumonia can cause a chronic cough.
6. Medication Side Effects: Some medications, particularly ACE inhibitors used for hypertension, can cause a chronic cough as a side effect.


Diagnostic Approach
Given the complexity of your symptoms, it is crucial to work closely with your healthcare provider. Here are some steps that may be taken:
- Further Testing: If you haven’t already, consider asking for a referral to an allergist or a gastroenterologist. They can perform specific tests to evaluate for allergies or GERD. A 24-hour pH monitoring test can help confirm GERD as a cause of your cough.

- Pulmonary Function Tests: If asthma is suspected, a repeat pulmonary function test may be warranted to assess your lung function and determine if your asthma is well-controlled.

- Imaging: If your cough persists despite treatment, a chest X-ray or CT scan may be necessary to rule out other conditions such as infections or structural abnormalities.


Treatment Options
1. Asthma Management: If asthma is confirmed, ensure you are using your inhaler correctly and consistently. Your doctor may adjust your medication regimen, possibly adding a corticosteroid inhaler for better control.

2. GERD Management: If GERD is suspected, lifestyle modifications such as avoiding trigger foods, eating smaller meals, and not lying down after eating can be beneficial. Medications like proton pump inhibitors (PPIs) may also be prescribed.

3. Allergy Treatment: If allergies are contributing to your symptoms, antihistamines or nasal corticosteroids may help alleviate postnasal drip and associated cough.

4. Cough Suppressants and Expectorants: Depending on the nature of your cough (dry vs. productive), your doctor may recommend specific cough medications to help manage symptoms.

5. Lifestyle Modifications: Staying hydrated, using a humidifier, and avoiding irritants such as smoke or strong odors can also help reduce coughing.


Conclusion
Persistent cough can arise from various causes, including asthma, GERD, postnasal drip, and chronic bronchitis. It is essential to work with your healthcare provider to identify the underlying cause and tailor a treatment plan that addresses your specific symptoms. If your cough persists despite current treatments, further evaluation and possibly a referral to a specialist may be necessary. Remember, effective management often requires a comprehensive approach that considers all potential contributing factors.

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