Do I Need Further HIV Testing After a Negative Saliva Test? - Internal Medicine

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Regarding saliva rapid test kits?


Hello doctor, I had unprotected sexual intercourse in early 2017.
In mid-2020, I used an HIV saliva test kit and received a negative result (one line).
Do I need to get tested again? I noticed that the CDC has been promoting blood testing kits recently.
Thank you.

Qiuqiu, 30~39 year old female. Ask Date: 2021/09/04

Dr. Lin Wufu reply Internal Medicine


Hello: The window period for HIV typically does not exceed six months.
Therefore, if unsafe sexual activity occurred three years ago and the current test result is negative, it should rule out infection.
However, saliva testing involves issues related to its sensitivity, and a negative result cannot guarantee that one is truly negative.
If there is still significant concern, it is advisable to undergo another blood test.

Reply Date: 2021/09/04

More Info


When it comes to HIV testing, understanding the implications of your results and the timing of your tests is crucial. Based on your situation, you had unprotected sexual intercourse in early 2017 and subsequently underwent an HIV saliva test in mid-2020, which returned a negative result. You are now questioning whether further testing is necessary, especially with the recent promotion of blood testing by health authorities.

Firstly, it is important to clarify the nature of the HIV saliva test you took. Saliva tests can be effective, but they are generally considered less sensitive than blood tests, particularly in the early stages of infection. The window period for saliva tests can vary, but it is typically around 3 months, meaning that if you were infected shortly before the test, there is a chance that the virus may not have been detected. However, since your test was conducted over three years after the potential exposure, it is highly unlikely that you would have contracted HIV during that time without it being detected.

The Centers for Disease Control and Prevention (CDC) recommends that individuals at high risk for HIV, or those who have had potential exposure, should be tested regularly. Given that your last potential exposure was in 2017 and you have since tested negative, the likelihood of being infected is very low. However, if you have had any new potential exposures since your last test, or if you have any symptoms that concern you, it would be wise to get tested again.

In addition, the introduction of blood testing is a positive development in HIV screening. Blood tests, particularly the fourth-generation tests that detect both HIV antibodies and antigens, are highly sensitive and can provide more reliable results than saliva tests. If you are considering further testing, opting for a blood test would be advisable, especially if you have any lingering concerns about your health or potential exposure.

Moreover, if you have been experiencing any symptoms such as unexplained weight loss, persistent fever, or night sweats, it is crucial to consult a healthcare provider. These symptoms can be associated with various health issues, including but not limited to HIV, and should be evaluated by a professional.

In summary, based on your negative saliva test in 2020 and the significant time that has passed since your last potential exposure, it is unlikely that you are HIV positive. However, if you have any new risks or symptoms, or if you simply want peace of mind, getting a blood test would be a prudent step. Regular testing is an essential part of maintaining sexual health, especially for those who may be at risk. Always consult with a healthcare provider for personalized advice and to discuss any concerns you may have regarding your health and HIV testing.

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