Your Rheumatology Test Results: What Do They Mean? - Internal Medicine

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Rheumatology and Immunology Examination Results


I have been experiencing pain in my shoulders, neck, arms, and fingers for three months, and rehabilitation has not improved my condition.
I consulted a rheumatologist, who ordered blood tests, and the results are as follows:
ESR: 5
Hb: 13.4
Hct: 38.0
MCH: 31.8
MCHC: 35.3
MCV: 90.3
PLT: 255
RBC: 4.21
RDW-CV: 14.2
RDW-SD: 46.7
WBC: 5.46
Ca: 9.2
P: 3.6
Creatinine: 0.7
eGFR (female): >60.000
Na: 138
K: 4.6
AST: 10
CK: 44
Mg (Magnesium): 2.10
RA: <12.0
CRP: <0.60
Hemolysis: 0
Icterus: 0
Lipemia: 0
C3: 109.0
C4: 29.9
PATTERN: Homogeneous 1/640 (Positive)
PATTERN 2: Speckled 1/640 (Positive)
HLA-B27: Negative
Given that two of the indices are as high as 1/640, does this indicate that I have a serious autoimmune disease? I am very worried since I have to wait another half month for my follow-up appointment.
Currently, I am continuing acupuncture treatment for the pain, and this week I have experienced significant improvement, with only occasional shoulder pain remaining.

Xiao Wen, 40~49 year old female. Ask Date: 2021/09/15

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your message.
The abnormal findings in your test report indicate a PATTERN of Homogeneous 1/640 (Positive) and a PATTERN of Speckled 1/640 (Positive), which are results for Antinuclear Antibodies (ANA).
Antinuclear antibodies are one of the screening indicators for autoimmune diseases; higher values suggest a greater potential for autoimmune conditions.
Therefore, your physician will arrange for further blood tests, taking into account your current clinical symptoms to make a final diagnosis.
However, it is important to note that some individuals may still have normal results even after further testing.
We consider these individuals to have this predisposition, where the abnormality can be detected in the body, but there is no actual autoimmune disease currently known.
Regular follow-up is often recommended for these cases.
So, please do not be overly anxious; just return for your follow-up appointment as scheduled.
The Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare, cares about you.

Reply Date: 2021/09/15

More Info


Understanding your rheumatology test results can indeed be a source of concern, especially when dealing with symptoms like shoulder, neck, and arm pain. Let's break down your results and what they might mean in the context of autoimmune diseases.

Your blood test results show several key indicators:
1. ESR (Erythrocyte Sedimentation Rate): At 5, this is within the normal range, suggesting that there is no significant inflammation present in your body at this time.

2. Hemoglobin (Hb) and Hematocrit (Hct): Both values are within normal limits, indicating that your red blood cell count is adequate and there is no anemia.

3. WBC (White Blood Cell Count): At 5.46, this is also within the normal range, suggesting that there is no acute infection or significant immune response occurring.

4. Platelet Count (PLT): At 255, this is within normal limits, indicating that your blood clotting ability is likely normal.

5. Creatinine and eGFR: Your creatinine level is low at 0.7, and the eGFR is greater than 60, which suggests good kidney function.

6. Calcium, Phosphorus, Sodium, Potassium, Magnesium: All these electrolytes are within normal ranges, indicating that your metabolic functions are stable.

7. RA (Rheumatoid Factor): A value of less than 12.0 is considered negative, which is a good sign as it suggests that rheumatoid arthritis is less likely.

8. CRP (C-reactive protein): At less than 0.60, this indicates that there is no significant inflammation present.

9. Complement levels (C3 and C4): These are within normal ranges, which is a positive indicator as low levels can be associated with autoimmune diseases.

10. Antinuclear Antibodies (ANA): The presence of a homogeneous pattern at a titer of 1:640 and a speckled pattern at the same titer indicates that there are autoantibodies present. While a titer of 1:640 is considered positive, it does not automatically mean you have a serious autoimmune disease. Many healthy individuals can have positive ANA tests without any underlying disease.

11. HLA-B27: A negative result here is also favorable, as this antigen is often associated with certain autoimmune conditions like ankylosing spondylitis.


Interpretation and Next Steps
The presence of positive ANA with a high titer can be concerning, but it is essential to remember that a positive ANA test alone does not confirm a diagnosis of an autoimmune disease. Many factors can lead to a positive ANA, including infections, medications, and even healthy individuals. The context of your symptoms, clinical history, and other test results are crucial for a proper diagnosis.

Given that your ESR, CRP, and other inflammatory markers are normal, it suggests that there is no active inflammatory process occurring in your body at this time. The improvement in your symptoms with acupuncture is also a positive sign, indicating that your pain may be related to muscular or mechanical issues rather than an autoimmune process.


Recommendations
1. Follow-Up: It is essential to follow up with your rheumatologist as planned. They will be able to interpret your results in the context of your symptoms and medical history.

2. Monitor Symptoms: Keep track of your symptoms, noting any changes or patterns. This information will be valuable for your doctor.

3. Consider Physical Therapy: Since you have not seen improvement with rehabilitation, discussing alternative therapies or adjustments to your current treatment plan with your healthcare provider may be beneficial.

4. Stay Informed: Educate yourself about autoimmune diseases and their symptoms, but avoid jumping to conclusions based on test results alone.

In summary, while your positive ANA results warrant further investigation, the absence of significant inflammation and the normal ranges of other tests are reassuring. Continue your treatments, monitor your symptoms, and maintain open communication with your healthcare provider.

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