Blood Test Results in Rheumatoid Arthritis Patients - Internal Medicine

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Rheumatoid arthritis blood test values


I have had rheumatoid arthritis (RA) for three years and have been on biologic therapy for about two years.
Since the onset of the disease, my blood test results have shown an ESR between 15-40.
Recently, during a follow-up visit, my blood report indicated RBC at 3.87, Neutrophils at 32.4, and Monocytes at 12.5, all highlighted in red.
What do these results signify? Is there anything I should be concerned about? (I have a rheumatologist who does not address my questions.
He believes that my symptoms, such as pain in the lumbar spine, neck, hip joints, headaches, weakness in my hands, and psoriasis, are not caused by RA.
He did not mention the blood report at all.) I still feel anxious internally, as my condition was not taken seriously due to the blood values, and it wasn't until I experienced pain in over ten joints that he was willing to prescribe medication (I currently feel that I may have developed a tolerance to the medication, and the pain has increased).

Maymay, 40~49 year old female. Ask Date: 2023/03/03

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your inquiry.
Your abnormal blood test results seem to be more related to the biologic therapy, but generally, they are not a major concern.
However, if you are still experiencing multiple joint pains despite receiving biologic treatment, it is important to discuss this with your physician.
If you do not receive satisfactory answers, you may seek a second opinion from another doctor.
The Allergy, Immunology, and Rheumatology Department at Changhua Hospital, Ministry of Health and Welfare, cares about your well-being.

Reply Date: 2023/03/03

More Info


Understanding blood test results in patients with rheumatoid arthritis (RA) can be quite complex, especially when dealing with various symptoms and treatment responses. In your case, the recent blood test results show abnormalities in red blood cells (RBC), neutrophils (Neutro), and monocytes (Mono). Let's break down what these values mean and their potential implications for your health.

1. RBC (Red Blood Cells): Your RBC count of 3.87 is slightly below the normal range, which typically falls between 4.2 to 5.9 million cells per microliter for men and 3.9 to 5.03 million cells per microliter for women. A low RBC count can indicate anemia, which is common in RA patients due to chronic inflammation, iron deficiency, or the effects of medications. Anemia can contribute to fatigue and weakness, which may explain some of your symptoms.

2. Neutrophils (Neutro): A neutrophil count of 32.4 is significantly elevated. Normal neutrophil levels typically range from 1.5 to 8.0 billion cells per liter. Elevated neutrophils can indicate an ongoing infection, inflammation, or stress response. In the context of RA, this could be a reaction to inflammation or a sign of an infection, especially if you are on immunosuppressive therapy like biologics, which can increase your risk of infections.

3. Monocytes (Mono): Your monocyte count of 12.5 is also elevated, as normal levels are generally between 0.2 to 0.8 billion cells per liter. Elevated monocytes can indicate chronic inflammation or infection. In RA, this can be related to the disease process itself, as monocytes play a role in the inflammatory response.

Given these results, it is crucial to discuss them with your healthcare provider. The combination of low RBC, high neutrophils, and high monocytes suggests that there may be an underlying inflammatory process or infection that needs to be addressed. It is also essential to consider your symptoms, such as joint pain, headaches, and skin issues, which could be related to RA or other conditions.

Your concerns about feeling unheard by your rheumatologist are valid. It is essential to have open communication with your healthcare provider. If you feel that your symptoms are not being adequately addressed, seeking a second opinion from another rheumatologist might be beneficial. They can provide a fresh perspective on your treatment plan and help you manage your symptoms more effectively.

Regarding your fear of medication resistance and the potential side effects of long-term medication use, these are common concerns among patients with chronic conditions. It is essential to have a balanced approach to medication management. Discussing your fears with your doctor can lead to a more tailored treatment plan that addresses both your RA and your concerns about medication side effects.

In summary, your blood test results indicate some abnormalities that warrant further investigation. It is crucial to communicate openly with your healthcare provider about your symptoms and concerns. Together, you can develop a comprehensive management plan that addresses both your RA and any other potential health issues. Remember, managing a chronic condition like RA often requires a multidisciplinary approach, including medication, lifestyle changes, and regular monitoring of your health status.

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