Does Estromon Increase Blood Clot Risk for Stroke Patients? - Pharmacology

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Medication contraindications


Several years ago, I had a stroke due to a cerebral thrombosis, and I have been taking anticoagulants regularly.
Now, due to discomfort related to menopause, my gynecologist has prescribed Estromon (estradiol).
Will this medication increase the risk of thrombosis? If so, are there alternative medications available?

Cindy, 50~59 year old female. Ask Date: 2021/09/29

Dr. Huang Shenggang reply Pharmacology


Hello Cindy: Thank you for your question.
The indications for Estromon (estrone) include vasomotor symptoms related to menopause, atrophic vaginitis, osteoporosis, vulvar dryness and atrophy, female gonadal insufficiency, primary ovarian insufficiency, hormonal imbalance-related dysfunctional uterine bleeding.
During the course of treatment, a small number of individuals may experience nausea, vomiting, and abdominal bloating.
Additionally, certain populations are advised against its use, including those with a history of breast cancer, high risk for endometrial cancer, unexplained vaginal bleeding, coronary artery disease, history of thromboembolic events or transient ischemic attacks, and active liver disease.
If you have any of these conditions, it is recommended that you discuss them with your physician.
There are also many treatment options for menopausal discomfort, and in addition to discussing with your current physician, you might consider exploring Traditional Chinese Medicine.
Thank you.

Reply Date: 2021/09/29

More Info


Estromon, a medication often prescribed for menopausal symptoms, contains a combination of estrogen and other components. For patients with a history of stroke, particularly those who have experienced a thrombotic event, the use of estrogen-containing medications raises significant concerns regarding the potential for increased thromboembolic events, including the risk of blood clots.

Estrogen is known to influence the coagulation system by increasing the levels of certain clotting factors and decreasing the levels of natural anticoagulants. This can lead to a hypercoagulable state, which is particularly concerning for individuals with a history of stroke or other thromboembolic events. Therefore, for a patient like yourself, who has a history of cerebral thrombosis and is currently on anticoagulants, the introduction of Estromon could indeed elevate the risk of developing blood clots.

Given these risks, it is crucial to have a thorough discussion with your healthcare provider. They can assess your individual risk factors, including your medical history, current medications, and overall health status, to determine whether the benefits of Estromon outweigh the potential risks. If there is a concern regarding the use of Estromon, there are alternative treatments for managing menopausal symptoms that may pose a lower risk for thromboembolic events.

Some alternatives to consider include:
1. Non-hormonal therapies: Medications such as selective serotonin reuptake inhibitors (SSRIs) or gabapentin can help alleviate hot flashes and mood swings associated with menopause without the risks associated with estrogen.

2. Lifestyle modifications: Regular exercise, a balanced diet, and maintaining a healthy weight can significantly improve menopausal symptoms and overall well-being.

3. Herbal supplements: Some women find relief with herbal remedies such as black cohosh or phytoestrogens (found in soy products), although these should be used with caution and under the guidance of a healthcare provider, especially considering potential interactions with anticoagulants.

4. Vaginal estrogen: If vaginal dryness is a significant issue, low-dose vaginal estrogen may be an option. This form of estrogen has a lower systemic absorption and may pose a reduced risk of thromboembolic events compared to systemic estrogen therapy.

In conclusion, while Estromon may provide relief from menopausal symptoms, its use in a patient with a history of stroke requires careful consideration of the associated risks. It is essential to work closely with your healthcare provider to explore safer alternatives that can effectively manage your symptoms without increasing your risk of blood clots. Always prioritize open communication with your healthcare team regarding any changes in your treatment plan.

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