Rheumatoid Arthritis: Symptoms, Triggers, and Healing Insights - Internal Medicine

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Rheumatoid Arthritis - Condition Monitoring and Questions


Hello, Dr.
Gao: I have been diagnosed with seronegative rheumatoid arthritis for one year and am currently taking pain relievers, corticosteroids, and immunomodulators (quinine/enteric-coated tablets).
My main symptoms are swelling and pain in my fingers and knees.
I have read that rheumatoid arthritis has periods of remission and exacerbation, but I have observed some patterns and would like to understand if there is a possibility of finding a path to recovery: 1.
My fingers swell after dinner (they reduce in swelling after digestion).
2.
My fingers swell during exercise (they reduce in swelling after finishing).
3.
Eating foods with chemical additives causes prolonged swelling (it takes a few days to improve).
Are these patterns normal? I have seen some literature suggesting that leaky gut syndrome and food sensitivities are closely related to autoimmune conditions, and that some medications can also damage the gastrointestinal mucosa.
Is this true? I am trying to eat healthy foods, but it is difficult to completely avoid the foods mentioned in the literature.
I tested for acute allergens and found only dust mites, but I have many chronic allergens.
Coincidentally, I started experiencing symptoms after avoiding these allergenic foods.
I have been on the medication for six months, but my condition has been fluctuating.
Are there any cases of recovery? How did they achieve it?

An Dong Ni, 30~39 year old female. Ask Date: 2021/10/03

Dr. Gao Jiankai reply Internal Medicine


Hello, thank you for your question.
I will assume that your condition is "seronegative rheumatoid arthritis" for my response.
Here is my summary:
1.
After dinner, your fingers swell (and the swelling subsides after digestion).
2.
During exercise, your fingers swell (and the swelling subsides after finishing).
3.
Consuming foods with added chemical processing causes prolonged swelling (which takes a few days to improve).
Are these patterns normal? --> These symptoms are relatively nonspecific, making it difficult to determine if they are related to your condition.
2.
I have read in some books that leaky gut syndrome/food is closely related to autoimmunity, and that some medications used for treatment can also damage the gastrointestinal mucosa.
Is this true? --> Gastrointestinal issues can indeed be related to autoimmune diseases, but this correlation is quite vague.
It would be better to more clearly define the specific gastrointestinal problems to provide a more accurate response.
For example, some inflammatory bowel diseases can also lead to arthritis.
Some medications can indeed harm the stomach, but the medications you are currently taking, quinine and sulfasalazine, do not harm the stomach.
In fact, sulfasalazine has therapeutic effects on inflammatory gastrointestinal diseases.
3.
You have been on medication for six months, and your condition has been fluctuating.
Are there any cases of complete recovery? How did they recover? --> It is important for you to take your medication regularly and have regular blood tests for monitoring.
If your blood test results remain normal and your symptoms improve, your physician may decide to reduce or even discontinue your medication based on your symptoms and blood test results.
Seronegative rheumatoid arthritis generally has a better prognosis than seropositive rheumatoid arthritis, so you might discuss with your physician the possibility of stopping medication in the future.
Best regards from the Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare.

Reply Date: 2021/10/03

More Info


Rheumatoid Arthritis (RA) is a chronic inflammatory disorder that primarily affects the joints but can also have systemic effects. Understanding the symptoms, triggers, and potential pathways to healing is crucial for managing this condition effectively.


Symptoms of Rheumatoid Arthritis
The hallmark symptoms of RA include joint pain, swelling, stiffness, and decreased range of motion. These symptoms often manifest symmetrically, meaning that if one hand or knee is affected, the other side is likely to be as well. Morning stiffness lasting more than an hour is also a common feature. In your case, you mentioned experiencing swelling in your fingers and knees, which aligns with typical RA symptoms.


Triggers of Rheumatoid Arthritis
Several factors can trigger or exacerbate RA symptoms. Based on your observations, it seems that certain activities and dietary choices may influence your condition:
1. Post-Meal Swelling: The swelling of your fingers after dinner that subsides afterward could be related to food intake. Some individuals with RA report that certain foods, particularly those high in sugar, processed ingredients, or additives, can trigger inflammation. This aligns with your observation that consuming chemically processed foods leads to prolonged swelling.

2. Exercise-Induced Swelling: It's not uncommon for joints to swell during or after physical activity, especially if the joints are already inflamed. However, the fact that they return to normal afterward suggests that the swelling may be temporary and related to increased blood flow and activity rather than a worsening of the underlying condition.

3. Chemical Additives: Your experience with swelling after consuming foods with chemical additives supports the theory that certain dietary components can influence autoimmune responses. This is where the concept of "leaky gut syndrome" comes into play, suggesting that intestinal permeability may allow undigested food particles to enter the bloodstream, potentially triggering an immune response.


The Role of Diet and Gut Health
The relationship between diet, gut health, and autoimmune diseases is an area of growing interest. Some studies suggest that a diet rich in anti-inflammatory foods (like fruits, vegetables, whole grains, and omega-3 fatty acids) may help manage symptoms. Conversely, processed foods, sugars, and certain allergens can exacerbate inflammation.

You mentioned that you have been trying to eat healthier, which is a positive step. While it may be challenging to avoid all potential triggers, focusing on whole, unprocessed foods can be beneficial. Additionally, maintaining a food diary to track your symptoms in relation to your diet may help identify specific triggers.


Healing Insights and Case Studies
While there is no definitive cure for RA, many patients experience significant improvement in their symptoms through a combination of medication, lifestyle changes, and dietary adjustments. Some individuals report remission or significant symptom reduction after implementing a holistic approach that includes:
- Medication: Continuing with your prescribed medications, including pain relievers, corticosteroids, and immunomodulators, is essential. If you find that your current regimen is not effective, discussing alternative medications with your healthcare provider may be necessary.

- Dietary Changes: Many patients have reported improvements by adopting an anti-inflammatory diet, which may include eliminating gluten, dairy, and processed foods while increasing the intake of fruits, vegetables, and healthy fats.

- Physical Activity: Regular, low-impact exercise can help maintain joint function and reduce stiffness. Activities like swimming, cycling, and yoga are often recommended.

- Stress Management: Stress can exacerbate autoimmune conditions, so incorporating stress-reducing practices such as mindfulness, meditation, or gentle yoga can be beneficial.


Conclusion
Your observations regarding swelling in relation to meals and activity are valid and suggest that your RA may be influenced by dietary and lifestyle factors. While healing from RA can be a complex journey, many patients find success through a combination of medical treatment, dietary changes, and lifestyle modifications. It’s essential to work closely with your healthcare provider to tailor a management plan that suits your specific needs and to explore any potential adjustments to your treatment regimen. Remember, every patient's experience with RA is unique, and finding the right balance may take time and patience.

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