COVID-19 Vaccination Guidelines for Patients on Hormonal Treatments - Obstetrics and Gynecology

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Administering the COVID-19 vaccine?


Can I receive the COVID-19 vaccine while having the effects of menopause injections (Dafeline) and Endometrin? I started menopause injections after undergoing endometriosis excision surgery.
Next Sunday, it will be six months since I received the menopause injection, and I will start taking Endometrin on October 10th.
Can I get the COVID-19 vaccine between October 13th (Wednesday) and October 15th (Friday)? (1) During this period, is it safe to administer the COVID-19 vaccine? (2) Is it safe to receive the vaccine while having the effects of the menopause injection and Endometrin in my system? Thank you!

olivia, 20~29 year old female. Ask Date: 2021/10/04

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, it is generally unrelated to vaccination.
Wishing you good health.

Reply Date: 2021/10/04

More Info


When considering COVID-19 vaccination for patients undergoing hormonal treatments, such as those receiving medications like Daphneline (a GnRH agonist) and Estrogen (like Estradiol), it is essential to evaluate both the safety and timing of the vaccination in relation to the treatment regimen.

1. Timing of Vaccination: Based on your timeline, you mentioned that you will be receiving Daphneline for six months and then transitioning to Estrogen (like Estradiol) starting on October 10. You are considering getting vaccinated between October 13 and October 15. Generally, it is advisable to receive the COVID-19 vaccine when you are feeling well and not undergoing any acute illness. Since you are transitioning between hormonal treatments, it is crucial to ensure that your body is stable and that you are not experiencing any significant side effects from the medications.
The Centers for Disease Control and Prevention (CDC) and other health authorities recommend that individuals who are on hormonal treatments can receive the COVID-19 vaccine. There is no evidence suggesting that hormonal treatments interfere with the efficacy of the vaccine or increase the risk of adverse effects. However, it is always best to consult with your healthcare provider to ensure that your specific health situation is taken into account.

2. Safety of Vaccination with Hormonal Treatments: The presence of Daphneline and Estrogen in your system should not pose any contraindications for receiving the COVID-19 vaccine. Hormonal treatments are not known to compromise the immune response to vaccines. In fact, maintaining a stable hormonal environment can be beneficial for overall health, which is important when considering vaccination.
It is important to monitor how you feel after receiving the vaccine, as some individuals may experience mild side effects such as fatigue, headache, or fever, which are common reactions to vaccines. If you experience any unusual symptoms or side effects that concern you, it is advisable to reach out to your healthcare provider for guidance.

3. Consultation with Healthcare Providers: Given your specific medical history, including the endometriosis and the hormonal treatments you are undergoing, it is crucial to have a discussion with your healthcare provider. They can provide personalized advice based on your overall health status, the medications you are taking, and any potential interactions. They may also recommend monitoring your health closely after vaccination, especially if you are transitioning between different hormonal therapies.

In conclusion, it is generally safe for individuals on hormonal treatments like Daphneline and Estrogen to receive the COVID-19 vaccine. The timing of your vaccination between October 13 and October 15 should be fine, provided you are feeling well. Always consult your healthcare provider to ensure that your vaccination plan aligns with your treatment regimen and overall health.

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