Can You Get the AZ Vaccine While Taking Tranexamic Acid and Birth Control? - Family Medicine

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Medication Consultation - Can I receive the AZ vaccine while taking tranexamic acid and birth control pills?


Hello Director Liao,
Last week, I was prescribed oral tranexamic acid for the treatment of rosacea on my face.
I only realized after a week that it should not be taken concurrently with the contraceptive pill I am using for adenomyosis, so I immediately stopped the tranexamic acid.
However, I am now scheduled for my second dose of the AZ vaccine and would like to know how long I should wait after stopping tranexamic acid before it is safe to receive the AZ vaccine.
Additionally, should I also stop the contraceptive pill before getting vaccinated for added safety? (I started taking the contraceptive pill one and a half months after the first vaccine dose, and I have been taking it for two and a half months now.)
I have had several episodes of palpitations over the past few years and have been classified as Category 9 (I was originally diagnosed with mitral valve prolapse, but follow-up assessments have shown no significant issues).
Given the medications mentioned, I am somewhat concerned about the risk of thrombosis.
It has been 15 weeks since my first vaccine dose, and I am worried that waiting too long for the BNT vaccine, which has no thrombosis concerns, might be detrimental.
Thank you in advance for your clarification, Director Liao!

C, 40~49 year old female. Ask Date: 2021/10/29

Dr. Liao Yaopan reply Family Medicine


Hello, there are currently no definitive research reports indicating that the two types of medications mentioned are contraindications for vaccination.
However, it is advisable to discuss with the prescribing physician whether to temporarily halt the use of these medications, taking into account the clinical circumstances.
Changhua Hospital cares about you.

Reply Date: 2021/10/29

More Info


When considering the administration of the AstraZeneca (AZ) vaccine while taking Tranexamic Acid and birth control pills, it is essential to understand the interactions and implications of these medications in relation to vaccination.
Firstly, Tranexamic Acid is primarily used to reduce bleeding by inhibiting fibrinolysis, which is the breakdown of blood clots. It is often prescribed for conditions that involve excessive bleeding, such as heavy menstrual periods or after certain surgeries. Birth control pills, on the other hand, are commonly used for contraception and can also help regulate menstrual cycles and reduce menstrual-related symptoms.

According to the information provided, there is currently no definitive research indicating that Tranexamic Acid or birth control pills are contraindications for receiving the AZ vaccine. This means that, in general, it is considered safe to receive the vaccine while taking these medications. However, it is always advisable to consult with the prescribing physician regarding your specific health circumstances, especially given your history of palpitations and mitral valve prolapse.
Regarding the timing of stopping Tranexamic Acid before vaccination, there is no established guideline that specifies a required waiting period. Since you have already ceased taking Tranexamic Acid, you should be in a suitable position to proceed with the vaccination. The key concern with any medication that affects blood clotting is the potential risk of thrombosis, particularly with the AZ vaccine, which has been associated with rare instances of thrombosis with thrombocytopenia syndrome (TTS). However, this risk is generally low, and the benefits of vaccination in preventing severe COVID-19 outcomes typically outweigh these risks.

As for the birth control pills, they are not known to interfere with the efficacy of the AZ vaccine. In fact, hormonal contraceptives can sometimes be beneficial in managing menstrual symptoms that may be exacerbated by the stress of vaccination or illness.
In terms of your concerns about the timing of the second dose of the AZ vaccine, it is important to note that while the recommended interval between doses is typically 8 to 12 weeks, some studies suggest that extending this interval may enhance the immune response. However, it is still advisable to complete the vaccination series as soon as possible to ensure optimal protection against COVID-19.

If you are experiencing symptoms such as ear imbalance, dizziness, or insomnia, it is crucial to discuss these with your healthcare provider before vaccination. While these symptoms may not contraindicate vaccination, they could potentially be exacerbated by the stress of the vaccination process or the immune response that follows.

Lastly, regarding the ongoing debates about mRNA vaccines and potential long-term effects, it is essential to rely on credible sources and ongoing research. Current evidence suggests that both mRNA and viral vector vaccines, including AZ, are safe and effective, with no significant long-term adverse effects reported in the general population.

In summary, you should be able to receive the AZ vaccine while taking birth control pills and after stopping Tranexamic Acid, but it is always best to consult with your healthcare provider for personalized advice. Your health history and current symptoms should be taken into account to ensure a safe and effective vaccination experience.

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