Can HPV Vaccine Be Administered to Those Over 45? - Urology

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Can the HPV vaccine be administered to individuals who are beyond the recommended age?


Doctor, may I ask if the HPV 9-valent vaccine is indicated for individuals aged 9 to 45, can a 46-year-old receive it? Will there be a higher likelihood of side effects? Thank you for your response.

Xiao Jie, 40~49 year old female. Ask Date: 2021/11/09

Dr. Du Shixi reply Urology


Hello: The reason for setting the age range of 9 to 45 years may be that individuals outside this range were not included in the drug trials, making it difficult to assess whether the side effects are more or less prevalent.
The drug's approved indications do not cover this age range, and if side effects occur, it may not be possible to apply for remediation.
Wishing you good health.
You can refer to https://www1.ndmctsgh.edu.tw/pharm/pic/medinsert/005GAR04.pdf.

Reply Date: 2021/11/09

More Info


The question of whether the HPV vaccine can be administered to individuals over the age of 45 is a pertinent one, especially given the increasing awareness of HPV-related health issues. The HPV vaccine, particularly the 9-valent vaccine, is primarily recommended for individuals aged 9 to 45. This age range is based on clinical trials that established the vaccine's safety and efficacy within this demographic.
For individuals aged 46 and older, the situation becomes more nuanced. While the vaccine is not officially approved for this age group, some healthcare providers may still recommend it based on individual circumstances. The rationale behind this recommendation is that the vaccine can still provide benefits, particularly for those who may be at risk of new HPV infections. However, it is essential to understand that the efficacy of the vaccine may not be as robust in older individuals, especially if they have already been exposed to certain HPV types.

Regarding the potential for side effects, there is no specific evidence to suggest that individuals over 45 will experience a higher incidence of adverse reactions compared to younger recipients. The side effects associated with the HPV vaccine are generally mild and can include pain at the injection site, fever, fatigue, and headaches. Serious side effects are rare. However, since the vaccine's safety profile has not been extensively studied in those over 45, it is advisable for individuals in this age group to consult with their healthcare provider to weigh the risks and benefits based on their health history and lifestyle.

Moreover, it is crucial to recognize that while the HPV vaccine can help prevent certain types of HPV infections, it does not treat existing infections or HPV-related diseases. Therefore, individuals who are already infected with HPV may not benefit from the vaccine in the same way that unvaccinated individuals would. This is particularly relevant for those who have had previous HPV-related health issues, such as cervical dysplasia or cancer.

In summary, while the HPV vaccine is primarily recommended for individuals aged 9 to 45, those over 45 may still consider vaccination based on their risk factors and discussions with their healthcare provider. It is essential to have a thorough understanding of one's health status and potential exposure to HPV before making a decision. Additionally, practicing safe sex, including the use of condoms, remains a critical strategy for reducing the risk of HPV transmission, regardless of vaccination status.
Ultimately, the decision to receive the HPV vaccine after the age of 45 should be made collaboratively with a healthcare provider, taking into account personal health history, potential exposure risks, and the overall benefits of vaccination in preventing future HPV-related health issues.

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