SCC Index in Health Checkups: What You Need to Know - Oncology

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SCC index in the medical examination report?


Hello Doctor, this year my menstrual cycle has been irregular for several months, with some delays.
I underwent a basic visual pelvic examination, and the doctor indicated that there were no abnormalities.
During the health check, additional tests for SCC and CA125 were performed.
The SCC level was above the normal range at 2.2 ng/ml (normal is 1.5 ng/ml), while the CA125 level was normal at 11.5 U/ml.
Other values from the health check and a chest X-ray showed no abnormalities.
However, I am quite anxious because my father was recently diagnosed with stage 2 lung adenocarcinoma.
I am unsure what further tests I should undergo or which specialty I should consult.
I have heard that elevated SCC levels can indicate risks for other cancers as well.
Thank you.

Ms. Chen, 30~39 year old female. Ask Date: 2021/11/12

Dr. Chen Yunfang reply Oncology


Hello: SCC is the tumor marker for squamous cell carcinoma, primarily used for monitoring head and neck cancers, esophageal cancer, certain types of lung cancer, and cervical cancer.
However, its correlation with actual cancer diagnosis is not absolutely accurate.
You can consult an otolaryngologist to rule out head and neck cancer, a gastroenterologist for an endoscopy to exclude esophageal cancer, a pulmonologist to check for lung cancer, and an obstetrician-gynecologist to rule out cervical cancer.
Thank you for your inquiry.

Reply Date: 2021/11/12

More Info


Understanding the SCC Index in Health Checkups: What You Need to Know
The SCC (Squamous Cell Carcinoma) antigen is a tumor marker that is primarily associated with squamous cell carcinoma, particularly of the lungs and cervix. It is important to note that while elevated SCC levels can indicate the presence of squamous cell carcinoma, they can also be elevated in other conditions, including benign diseases and other types of cancers. In your case, your SCC level was reported at 2.2 ng/ml, which is above the normal threshold of 1.5 ng/ml. However, your CA-125 level was normal at 11.5 U/ml.

Given your recent health concerns, especially with your father's diagnosis of stage II lung adenocarcinoma, it is understandable that you are feeling anxious about your own health. Here are some key points to consider regarding your SCC results and what steps you might take next:
1. Understanding SCC Levels: An elevated SCC level does not definitively indicate cancer. It can be influenced by various factors, including inflammation, infections, or other benign conditions. Therefore, while your level is elevated, it is essential to interpret it in the context of your overall health and any symptoms you may be experiencing.

2. Consulting a Specialist: Given your elevated SCC level and family history of cancer, it would be prudent to consult with a specialist. A medical oncologist or a hematologist-oncologist would be well-equipped to evaluate your situation further. They can provide a comprehensive assessment and determine if additional testing is warranted.

3. Further Testing: Depending on your doctor's recommendations, further tests may include imaging studies (like a CT scan or MRI) to check for any abnormalities in the lungs or other areas of concern. Additionally, they may suggest a biopsy if any suspicious lesions are found.

4. Monitoring Symptoms: Pay attention to any new symptoms that may arise, such as persistent cough, unexplained weight loss, or changes in your menstrual cycle. Documenting these changes can provide valuable information to your healthcare provider.

5. Regular Check-ups: Regular follow-ups with your healthcare provider are essential. They may recommend periodic monitoring of your SCC levels and other relevant tests to track any changes over time.

6. Lifestyle Considerations: While awaiting further evaluation, consider adopting a healthy lifestyle that includes a balanced diet, regular exercise, and avoiding smoking and excessive alcohol consumption. These factors can contribute to overall health and may help mitigate cancer risk.

7. Emotional Support: Dealing with health concerns, especially in light of a family member's cancer diagnosis, can be emotionally taxing. Consider seeking support from friends, family, or professional counselors to help manage anxiety and stress.

In summary, while your elevated SCC level warrants further investigation, it is crucial to approach the situation with a balanced perspective. Consult with a specialist, consider additional testing, and maintain regular health check-ups. Remember that many factors can influence tumor markers, and an elevated level does not automatically mean cancer. Stay proactive about your health, and ensure you have a support system in place as you navigate this process.

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