Breast Tumors: What to Expect After a BI-RADS 4A Diagnosis - Breast and Thyroid

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Breast tumor


I recently had an ultrasound at the hospital that revealed a tumor measuring 0.5 x 0.8 cm, classified as BI-RADS 4A.
I immediately underwent four core needle biopsies, and next week I will return to review the report.
The doctor mentioned that it is benign.
Additionally, a mammogram was performed, which reported extremely dense breast tissue (BI-RADS category D) and an ill-defined distortion lesion in the left upper inner breast, classified as ACR BI-RADS Category IVb.
The doctor has advised me to undergo another mammogram biopsy.
Is it possible that this could still be malignant? Could repeated imaging and biopsies cause harm? Is it possible to skip the biopsy and proceed directly to surgery to remove it?

Xiao Wu, 50~59 year old female. Ask Date: 2021/12/20

Dr. Yuan Tianmin reply Breast and Thyroid


The area targeted for ultrasound biopsy may not necessarily correspond to the area seen on a mammogram.
For lesions identified on a mammogram, there are two approaches: one is to perform a biopsy, and the other is to excise the entire lesion.
Both options are available, and you can discuss them with your physician.

Reply Date: 2021/12/20

More Info


When faced with a BI-RADS 4A diagnosis, it’s understandable to feel anxious and uncertain about the next steps. The BI-RADS (Breast Imaging Reporting and Data System) classification is a standardized system used by radiologists to categorize breast imaging findings, particularly from mammograms and ultrasounds. A BI-RADS 4A classification indicates a suspicious abnormality that has a low likelihood of being malignant (about 2-10% chance), but it still warrants further investigation, typically through a biopsy.

In your case, the initial ultrasound revealed a tumor measuring 0.5 x 0.8 cm, and subsequent core needle biopsies indicated that the tumor is benign. However, the additional mammogram findings of an "ill-defined distortion lesion" categorized as BI-RADS 4B suggest that there is still some concern regarding the potential for malignancy. This discrepancy between the benign biopsy results and the mammogram findings can understandably lead to confusion and concern.

The recommendation for further imaging or biopsy is not uncommon in cases where there are conflicting results. The purpose of these additional tests is to ensure that any potential malignancy is not missed. While it may seem repetitive and concerning to undergo multiple procedures, it is essential to understand that these steps are taken to ensure your safety and health. The risk of radiation exposure from mammograms is relatively low, especially when weighed against the potential benefits of early detection of breast cancer. The cumulative risk from multiple imaging studies is generally considered acceptable, particularly when the findings are suspicious.

Regarding your question about whether a second biopsy could reveal malignancy, it is important to note that while the initial biopsy indicated a benign tumor, the presence of the ill-defined lesion on the mammogram necessitates further evaluation. The possibility of malignancy cannot be entirely ruled out until all tests are completed and reviewed comprehensively by your healthcare team.

As for the option of surgical removal without further biopsy, this is a discussion you should have with your healthcare provider. In some cases, if a lesion is highly suspicious and the patient is anxious about the wait for further testing, a surgeon may recommend excisional biopsy (removal of the lesion) as a definitive approach. However, this decision should be made collaboratively with your medical team, considering all the risks and benefits.

In summary, after a BI-RADS 4A diagnosis, it is crucial to follow through with the recommended imaging and biopsies to ensure a comprehensive evaluation of the breast lesion. While the initial findings may be reassuring, the presence of additional suspicious findings necessitates further investigation. Open communication with your healthcare provider about your concerns and preferences is vital in navigating this process. Remember, early detection and intervention are key in managing breast health effectively.

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