Dopamine homeostasis issues in the brain?
Hello.
I have some questions after reading a medical article online.
Does this mean that if we only engage in pleasurable activities, our internal balance will lead us towards feelings of sadness? Doesn't this imply that we can't be happy all the time? This idea is a bit frightening to me.
The logic seems quite strange.
So, are we not allowed to do things that make us happy? If we do too many enjoyable activities, will it lead to feelings of sadness? Or am I misunderstanding something from the medical article?
When we engage in activities we enjoy—like playing video games for my patients—our brains release a bit of dopamine, and we feel good.
However, one of the most significant discoveries in neuroscience over the past 75 years is that pleasure and pain are processed in the same part of the brain, which works to maintain a balance between them.
Whenever it tilts in one direction, it strives to restore balance by tilting in the opposite direction, a concept neuroscientists refer to as homeostasis.
Once dopamine is released, the brain adapts by reducing or "downregulating" the number of stimulated dopamine receptors.
This leads the brain to tilt towards the pain side to regain balance, which is why feelings of a hangover or emotional low often follow pleasure.
If we wait long enough, this feeling will pass, and a neutral state will be restored.
If we maintain a gaming mode for several hours a day, for weeks or months, the brain's set point for pleasure will change.
Now we need to continue playing games, not for pleasure, but to normalize what is considered normal.
Once we stop, we will experience withdrawal symptoms common to any addictive substance: anxiety, irritability, insomnia, restlessness, and a mental focus on the use, also known as cravings.
Brian, 30~39 year old female. Ask Date: 2021/12/30
Dr. Wu Enliang reply Psychiatry
Hello, netizen: This article primarily explains the mechanisms of addiction and should not be overly quoted out of context in relation to activities that do not lead to addiction.
Dr.
Wu Enliang.
Reply Date: 2021/12/30
More Info
Understanding the balance of dopamine in the brain is crucial for comprehending how our emotions fluctuate between happiness and sadness. Dopamine is a neurotransmitter that plays a significant role in the brain's reward system, influencing feelings of pleasure, motivation, and mood regulation. When we engage in activities that we enjoy—such as playing video games, socializing, or eating delicious food—our brain releases dopamine, which creates a sense of pleasure and satisfaction.
However, the concept of "homeostasis" or "internal balance" in neuroscience suggests that the brain strives to maintain equilibrium between pleasure and pain. This means that when we experience a spike in happiness due to dopamine release, the brain may subsequently adjust by reducing the number of dopamine receptors or the sensitivity of these receptors. This adjustment can lead to a feeling of emotional low or a "hangover" effect after the initial pleasure fades. Essentially, the brain's way of balancing the scales can result in a temporary dip in mood following a high.
It's important to note that this mechanism does not imply that we should avoid activities that bring us joy. Instead, it highlights the brain's natural regulatory processes. Engaging in pleasurable activities is a normal part of life, and while it may lead to fluctuations in mood, these feelings are typically transient. The brain's ability to return to a neutral state after experiencing highs and lows is a testament to its resilience.
The concern that one cannot be happy all the time is valid, but it is essential to understand that mood fluctuations are a normal aspect of human experience. Engaging in a variety of activities—both pleasurable and neutral—can help mitigate the intensity of these mood swings. For instance, incorporating physical exercise, mindfulness practices, and social interactions can promote overall emotional well-being and help stabilize dopamine levels.
Moreover, the risk of developing addictive behaviors arises when individuals excessively engage in activities that provide a dopamine rush, such as gaming or substance use. Over time, the brain may require more stimulation to achieve the same level of pleasure, leading to a cycle of dependency. This is why moderation is key; enjoying pleasurable activities in a balanced manner can prevent the brain from becoming overly reliant on them for happiness.
In summary, while the brain's dopamine system does create a dynamic interplay between pleasure and pain, it does not mean that we should shy away from activities that make us happy. Instead, understanding this balance can empower us to engage in a variety of experiences that contribute to our overall well-being. Embracing both the highs and lows of emotional experiences can lead to a more fulfilling life, where joy is appreciated, and challenges are navigated with resilience.
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