The Balance of Dopamine in the Brain: Happiness and Mood Swings - Psychiatry

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Dopamine homeostasis in the brain?


Hello.
I have some questions after reading a medical article online.
Does this mean that if we only engage in pleasurable activities, our internal balance will lead us towards feeling down? Doesn't this imply that we cannot be happy all the time? This idea is somewhat frightening to me.
The logic seems quite strange.
So, are we not allowed to do things that make us happy? If we do too many enjoyable things, will it lead to feeling down? Or am I misunderstanding something from the medical article?
When we engage in activities we enjoy—like playing video games for my patients—our brain releases a bit of dopamine, making us feel good.
However, one of the most significant discoveries in neuroscience over the past 75 years is that pleasure and pain are processed in the same part of the brain, which works to maintain a balance between them.
Whenever it tilts in one direction, it strives to restore equilibrium by tilting in the opposite direction, a concept known as homeostasis.
Once dopamine is released, the brain adapts by reducing or "downregulating" the number of stimulated dopamine receptors.
This leads the brain to tilt towards the pain side to regain balance, which is why we often experience a hangover or a low mood after feeling happy.
If we wait long enough, this feeling will pass, and a neutral state will be restored.

If we maintain a gaming mode for several hours each day for weeks or months, the brain's set point for happiness will change.
Now, we need to continue playing games not for pleasure, but to normalize what is considered normal.
Once we stop, we will experience common withdrawal symptoms similar to those of any addictive substance: anxiety, irritability, insomnia, restlessness, and a mental focus on usage, also known as cravings.

Brian, 30~39 year old female. Ask Date: 2022/01/01

Dr. Wu Enliang reply Psychiatry


Hello, netizen: This article primarily explains the mechanisms of addiction and should not be overly quoted out of context in relation to activities that do not lead to addiction.
Dr.
Wu Enliang.

Reply Date: 2022/01/01

More Info


The balance of dopamine in the brain is a complex and fascinating topic that touches on our experiences of happiness, pleasure, and even mood swings. Your concerns about the implications of dopamine release and its effects on our emotional states are valid and reflect a common misunderstanding of how our brain's reward system operates.

Dopamine is often referred to as the "feel-good" neurotransmitter because it plays a crucial role in the brain's reward system. When we engage in activities that we enjoy—such as playing video games, socializing, or eating delicious food—dopamine is released, creating feelings of pleasure and satisfaction. However, as you pointed out, there is a phenomenon known as "homeostasis" or "internal balance" in the brain, which means that for every high, there is a corresponding low.

This concept can be summarized by the idea that the brain strives to maintain equilibrium. When dopamine levels spike due to pleasurable activities, the brain may respond by reducing the sensitivity or number of dopamine receptors. This adjustment can lead to a feeling of emotional low or a "hangover" effect after the initial pleasure fades. This is not to say that engaging in enjoyable activities is inherently bad or that it will always lead to negative feelings afterward. Rather, it highlights the brain's adaptive mechanisms in response to repeated stimulation.

Your concern about whether we should avoid doing things that make us happy is understandable, but it's important to clarify that this does not mean we should stop pursuing joy. Engaging in pleasurable activities is essential for our mental health and overall well-being. The key lies in moderation and variety. When we indulge excessively in a single source of pleasure—like playing video games for hours every day—our brain's reward system can become desensitized, leading to a need for more stimulation just to feel "normal." This can create a cycle where we feel compelled to continue the activity not for enjoyment, but to avoid feeling low.

In a healthy lifestyle, it is crucial to balance activities that bring joy with other fulfilling experiences. This could include physical exercise, social interactions, creative pursuits, and mindfulness practices. These activities can help maintain a balanced dopamine level without leading to the negative consequences associated with overindulgence in any single activity.

Moreover, it’s essential to recognize that the feelings of anxiety, irritability, or restlessness you mentioned—often associated with withdrawal from pleasurable activities—are typically temporary and can be managed through various coping strategies. Engaging in different hobbies, spending time with friends, or practicing relaxation techniques can help alleviate these feelings.

In conclusion, while the brain's dopamine system does indeed work to maintain balance, this does not mean we should shy away from activities that bring us joy. Instead, we should aim for a balanced approach to pleasure, ensuring that we engage in a variety of activities that contribute to our overall happiness and well-being. If you find yourself struggling with feelings of low mood or anxiety, it may be beneficial to speak with a mental health professional who can provide guidance tailored to your individual needs.

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Hello, netizen: Yes, please don't worry. Dr. Wu En-liang.

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