Dopamine homeostasis issues in the brain?
Hello.
I have some questions after reading a medical article online.
Does this mean that if we only engage in pleasurable activities, our internal balance will lead us towards feelings of sadness? Doesn't this imply that we cannot be happy all the time? This idea is somewhat frightening to me.
The logic seems quite strange.
So, are we not allowed to do things that make us happy? If we do too many pleasurable activities, will it lead to feelings of sadness? Or am I misunderstanding something from the medical article?
When we engage in activities we enjoy—like playing video games for my patients—our brain releases a bit of dopamine, making us feel good.
However, one of the most significant discoveries in neuroscience over the past 75 years is that pleasure and pain are processed in the same part of the brain, which strives to maintain a balance between them.
Whenever it tilts in one direction, it works to restore balance by tilting in the opposite direction, a concept known as homeostasis.
Once dopamine is released, the brain adapts by reducing or "downregulating" the number of stimulated dopamine receptors.
This leads the brain to tilt towards the pain side to regain balance, which is why we often experience a "hangover" or feelings of sadness after pleasure.
If we wait long enough, this feeling will pass, and the neutral state will be restored.
If we maintain a gaming mode for several hours a day, for weeks or months, the brain's set point for pleasure will change.
Now we need to continue playing not for pleasure, but to normalize what is considered normal.
Once we stop, we will experience withdrawal symptoms common to any addictive substance: anxiety, irritability, insomnia, restlessness, and a mental focus on the substance used, also known as cravings.
Brian, 30~39 year old female. Ask Date: 2021/12/31
Dr. Wu Enliang reply Psychiatry
Hello, netizen: This article primarily explains the mechanisms of addiction and should not be overly quoted out of context in relation to activities that do not lead to addiction.
Dr.
Wu Enliang
Reply Date: 2021/12/31
More Info
The balance of dopamine in the brain is a complex and fascinating topic, particularly when it comes to understanding joy and mood swings. Dopamine is a neurotransmitter that plays a crucial role in the brain's reward system, influencing feelings of pleasure, motivation, and mood regulation. When we engage in activities that we find enjoyable, such as playing video games or spending time with loved ones, our brain releases dopamine, leading to feelings of happiness and satisfaction. However, the relationship between dopamine and our emotional states is not as straightforward as it may seem.
The concept of homeostasis in the brain suggests that it strives to maintain a balance between pleasure and pain. When we experience a surge of happiness due to dopamine release, the brain may respond by downregulating dopamine receptors. This means that over time, the same activities that once brought us joy may not elicit the same response, leading to a phenomenon often referred to as "hedonic adaptation." As a result, individuals may find themselves needing to engage in these pleasurable activities more frequently or intensely to achieve the same level of satisfaction, which can lead to a cycle of dependency.
Your concern about whether engaging in enjoyable activities can lead to feelings of sadness or low mood is valid. This phenomenon is often described as a "pleasure hangover," where the initial high from a pleasurable experience is followed by a dip in mood. This can be particularly pronounced if someone engages in these activities excessively, as the brain's reward system becomes desensitized. When the activity is stopped or reduced, withdrawal-like symptoms can occur, including anxiety, irritability, and restlessness—similar to what is experienced with substance withdrawal.
It's important to clarify that this does not mean we should avoid doing things that make us happy. Instead, it highlights the importance of moderation and balance in our activities. Engaging in a variety of activities, including physical exercise, social interactions, and creative pursuits, can help maintain a healthy dopamine balance. Additionally, practicing mindfulness and being aware of our emotional states can aid in recognizing when we might be leaning too heavily on certain activities for happiness.
Moreover, the brain's neuroplasticity allows it to adapt and change over time. By diversifying the sources of joy and incorporating new experiences, we can help prevent the brain from becoming overly reliant on a single source of pleasure. This approach not only enhances overall well-being but also fosters resilience against mood swings and emotional lows.
In summary, while the brain does strive for balance between pleasure and pain, this does not mean we should shy away from activities that bring us joy. Instead, understanding the dynamics of dopamine and emotional regulation can empower us to make healthier choices, engage in a variety of fulfilling activities, and maintain a balanced emotional state. If you find that your mood swings or feelings of anxiety are becoming overwhelming, it may be beneficial to seek guidance from a mental health professional who can provide support and strategies tailored to your needs.
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