Dopamine Balance: The Science Behind Happiness and Mood Swings - Psychiatry

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Dopamine homeostasis issues in the brain?


Hello.
I have some questions after reading a medical article online.
Does this mean that if we only engage in pleasurable activities, our internal balance will lead us towards feelings of sadness? Doesn't this imply that we cannot be happy all the time? This idea is a bit frightening to me.
The logic seems quite strange.
So, are we not allowed to do things that make us happy? Will doing too many pleasurable activities lead to feelings of sadness? Or am I misunderstanding something from the medical article?
When we engage in activities we enjoy—like playing video games for my patients—our brains release a bit of dopamine, and we feel good.
However, one of the most significant discoveries in neuroscience over the past 75 years is that pleasure and pain are processed in the same part of the brain, which works to keep them balanced.
Whenever it tilts in one direction, it strives to restore balance by tilting in the opposite direction, a concept neuroscientists refer to as homeostasis.
Once dopamine is released, the brain adapts by reducing or "downregulating" the number of stimulated dopamine receptors.
This leads the brain to tilt towards the pain side to regain balance, which is why feelings of a hangover or emotional low often follow pleasure.
If we wait long enough, this feeling will pass, and the neutral state will be restored.

If we maintain a gaming mode for several hours each day, for weeks or months, the brain's set point for pleasure will change.
Now we need to continue playing not for pleasure, but to normalize what is considered normal.
Once we stop, we will experience withdrawal symptoms common to any addictive substance: anxiety, irritability, insomnia, restlessness, and a mental focus on usage, also known as cravings.

Brian, 30~39 year old female. Ask Date: 2022/01/02

Dr. Wu Enliang reply Psychiatry


Hello, internet user: This article primarily explains the mechanisms of addiction and should not be overly quoted out of context in relation to activities that do not lead to addiction.
Dr.
Wu Enliang.

Reply Date: 2022/01/02

More Info


Understanding the balance of dopamine in the brain is crucial to comprehending how our emotions fluctuate between happiness and sadness. The concept of "homeostasis" in neuroscience suggests that our brains strive to maintain a balance between pleasure and pain. When we engage in activities that bring us joy, such as playing video games or socializing, our brains release dopamine, a neurotransmitter associated with pleasure and reward. However, this release is not without consequences.

The brain's reward system is designed to ensure that we do not remain in a state of constant pleasure. When dopamine is released, the brain adapts by reducing the number of dopamine receptors available. This process is known as "downregulation." As a result, after experiencing a high level of pleasure, we may find ourselves feeling low or experiencing a "hangover" effect. This is a natural response as the brain attempts to restore balance. Over time, if we continually engage in high-dopamine activities, our baseline level of happiness may shift, requiring us to engage in these activities more frequently just to feel "normal." This can lead to a cycle of dependency, where the pursuit of pleasure becomes necessary to avoid feelings of discomfort or withdrawal.

It is essential to clarify that this phenomenon does not imply that we should avoid activities that bring us joy. Engaging in pleasurable activities is a vital part of a healthy life. The key is moderation and variety. Activities that promote happiness, such as socializing, exercising, or pursuing hobbies, can contribute positively to our mental health when balanced with other aspects of life.
Moreover, the concern that engaging too much in pleasurable activities will lead to chronic sadness is somewhat exaggerated. While it is true that the brain's reward system can become desensitized, this does not mean that normal, healthy activities will inevitably lead to negative emotional states. The brain is remarkably resilient and capable of returning to a state of equilibrium after periods of intense pleasure.

In the context of addiction, the stakes are higher. When individuals engage in activities that lead to excessive dopamine release—such as substance abuse or compulsive behaviors—the brain's reward system can become significantly altered. This can result in withdrawal symptoms when the activity is stopped, including anxiety, irritability, and cravings. These symptoms are similar to those experienced by individuals withdrawing from addictive substances.

In summary, while the brain's dopamine system does exhibit a balancing act between pleasure and pain, this does not mean that we should shy away from activities that make us happy. Instead, we should aim for a balanced approach to pleasure, incorporating a variety of activities that contribute to our overall well-being. Understanding this balance can help alleviate fears about engaging in joyful activities and encourage a healthier relationship with pleasure and reward in our lives.

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