Autoimmunity
Hello Doctor, I went to see a dermatologist for hair loss and had a blood test, which showed an ANA value of 80, negative.
The doctor told me to see a rheumatologist if I experience joint pain or related issues.
I would like to ask: 1.
Are there any methods to prevent the ANA from rising further? 2.
Does an ANA of 80 negative mean it will not decrease further or even reach 0? 3.
What should I be aware of regarding the presence of abnormal antibodies in my body? 4.
I have a history of allergies, and I have had three blood tests recently, with eosinophils consistently elevated around 10-11.
I have allergic rhinitis and occasional bronchitis.
Recently, I had an abdominal ultrasound that showed gallstones and fatty liver.
I read that fatty liver can cause chronic liver inflammation, but my liver function tests are normal.
Could these factors also influence the ANA value? I understand that a value over 160 has clinical significance, but I am still worried it might get worse.
🥺 Thank you for your response, Doctor.
Nana, 20~29 year old female. Ask Date: 2022/01/07
Dr. Gao Jiankai reply Internal Medicine
Hello, thank you for your questions.
Here are my responses:
1.
Is there any way to prevent ANA levels from rising? --> A positive ANA is part of an individual's constitution and generally does not change significantly.
However, slight variations may occur due to differences in laboratory equipment used by different hospitals.
Therefore, even if there are minor changes, there is no need for excessive concern.
2.
If an ANA titer of 80 is negative, will it not decrease further or even reach zero? --> My response is the same as above.
3.
Are there any precautions to take when abnormal antibodies are detected in the body? --> It is possible for healthy individuals to also detect abnormal antibodies; the key factor is whether symptoms are present.
If there are no symptoms, it is generally recommended to maintain a regular routine, engage in regular exercise, and follow up every six months to a year.
4.
I have a history of allergies and have had three blood tests recently showing elevated eosinophils around 10-11.
I have allergic rhinitis and occasional bronchitis.
Recently, I had an abdominal ultrasound that revealed gallstones and fatty liver.
I read online that fatty liver can cause chronic liver inflammation, but my liver function tests are normal.
Could these factors also influence my ANA levels? --> ANA levels may be related to liver disease, as certain liver conditions can result in elevated ANA titers.
The relationship between the two is complex and should be evaluated by a healthcare professional.
If you have these concerns, it is advisable to consult your primary care physician for a comprehensive assessment.
Best regards from the Allergy, Immunology, and Rheumatology Department of Changhua Hospital, Ministry of Health and Welfare.
Reply Date: 2022/01/07
More Info
Understanding ANA (Antinuclear Antibody) levels is crucial for evaluating potential autoimmune conditions. Your recent ANA test result of 1:80, which is considered negative, raises several important questions regarding its implications and management. Here’s a detailed response to your inquiries:
1. Can ANA levels be prevented from rising?
ANA levels can fluctuate due to various factors, including genetic predisposition, environmental triggers, and underlying health conditions. While there is no definitive method to prevent ANA levels from increasing, maintaining a healthy lifestyle can be beneficial. This includes regular exercise, a balanced diet, adequate hydration, and stress management. Additionally, avoiding known triggers, such as certain medications or infections, may help stabilize your immune response. Regular follow-ups with your healthcare provider can also ensure that any changes in your health status are monitored closely.
2. Will an ANA level of 1:80 remain stable or decrease?
An ANA level of 1:80 is considered low and typically does not indicate a significant autoimmune issue, especially if there are no accompanying symptoms. It is important to understand that ANA levels can vary over time due to numerous factors, including changes in your health status or immune system activity. While it is possible for ANA levels to decrease or even return to zero, it is equally possible for them to remain stable or fluctuate. Continuous monitoring through regular blood tests is advisable, especially if you develop new symptoms.
3. What should be noted about the presence of abnormal antibodies?
The presence of abnormal antibodies, such as ANA, does not automatically indicate a disease. Many individuals with positive ANA tests remain asymptomatic and do not develop autoimmune diseases. The key factors to consider are the presence of symptoms and the clinical context. If you experience symptoms such as joint pain, fatigue, or skin rashes, further evaluation may be warranted. It is essential to maintain open communication with your healthcare provider about any new or worsening symptoms.
4. Could my allergies and other health issues affect my ANA levels?
Yes, your allergic conditions and other health issues could potentially influence your ANA levels. Conditions like allergic rhinitis and asthma can lead to immune system activation, which might result in fluctuating ANA levels. Additionally, liver conditions such as fatty liver disease can also be associated with elevated ANA levels. However, since your liver function tests are normal, it is less likely that your fatty liver is significantly impacting your ANA levels. It is crucial to discuss these concerns with your healthcare provider, who can help determine if further investigation is necessary.
In summary, while an ANA level of 1:80 is not typically concerning, it is essential to monitor your health and any symptoms you may experience. Regular check-ups with your healthcare provider will help ensure that any potential autoimmune issues are addressed promptly. Remember, the interpretation of ANA results should always be done in conjunction with clinical findings and symptoms. If you have ongoing concerns or new symptoms, do not hesitate to seek further evaluation from a rheumatologist or your primary care physician.
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