Elevated high-sensitivity C-reactive protein (hs-CRP) levels?
This year, during the company's health check-up, I paid for heart-related tests, and the result for high-sensitivity C-reactive protein (hs-CRP) was extremely high at 3.248 (with a reference value of <0.3).
I found online that this level indicates a high risk for myocardial infarction.
However, I remembered that on the day of the test, I had gastroenteritis and had been experiencing diarrhea for two days without seeking medical attention.
Since all other test results were normal except for this elevated level, I would like to ask the doctor if the gastroenteritis could have influenced the result.
Would the doctor recommend that I return for a retest? I am 33 years old this year.
Ru, 30~39 year old female. Ask Date: 2022/01/12
Dr. Cai Guiqin reply Cardiology
It is recommended that you discuss the above situation with your attending physician to determine if further examinations are necessary.
Thank you, and wishing you good health!
Reply Date: 2022/01/12
More Info
High-sensitivity C-reactive protein (hs-CRP) is a biomarker that is widely used to assess inflammation in the body. Elevated levels of hs-CRP can indicate an increased risk of cardiovascular diseases, including myocardial infarction (heart attack) and other heart-related conditions. In your case, a hs-CRP level of 3.248 mg/L, significantly above the normal range (<0.3 mg/L), raises concerns about potential cardiovascular risks. However, it is essential to consider the context in which this test was performed, particularly your recent gastrointestinal issues.
Gastrointestinal inflammation, such as that caused by gastroenteritis, can lead to elevated levels of CRP. This is because CRP is an acute-phase reactant produced by the liver in response to inflammation, regardless of the source. When the body is fighting an infection or inflammation, such as from a gastrointestinal infection, CRP levels can rise significantly. Therefore, it is plausible that your recent bout of gastroenteritis could have contributed to the elevated hs-CRP levels observed in your test results.
Given that your other tests were normal and considering your recent health issues, it would be prudent to discuss your situation with your healthcare provider. They may recommend retesting your hs-CRP levels after your gastrointestinal symptoms have resolved to determine if the elevation was indeed related to your recent illness. This follow-up can help clarify whether the high hs-CRP level is indicative of an ongoing cardiovascular risk or if it was a transient response to your gastrointestinal condition.
In addition to retesting, your doctor may also consider other cardiovascular risk factors, including your family history, lifestyle factors (such as diet and exercise), and any other relevant medical history. It is essential to have a comprehensive evaluation to understand your overall cardiovascular risk better.
Furthermore, if your hs-CRP levels remain elevated after your gastrointestinal symptoms have resolved, your healthcare provider may suggest additional diagnostic tests, such as imaging studies or further blood tests, to assess your heart health more thoroughly. This could include tests like a lipid panel, echocardiogram, or even a stress test, depending on your specific risk profile and symptoms.
In summary, while elevated hs-CRP levels can indicate an increased risk for cardiovascular events, it is crucial to interpret these results in the context of your overall health and recent gastrointestinal issues. A follow-up with your healthcare provider is essential to determine the appropriate next steps, including potential retesting and further evaluation of your cardiovascular health. Always remember that proactive management of your health, including regular check-ups and discussions with your healthcare provider, is vital in mitigating risks and ensuring your well-being.
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