High Ferritin Levels: What You Need to Know - Family Medicine

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The ferritin (EIA) index in the health examination report is elevated?


Hello Doctor, I had a health check-up at the municipal hospital on September 22 (pre-marital check-up), which included blood, urine, stool tests, ultrasound, and X-rays.
Today I received the report, and only three indices are flagged as abnormal: 1.
Uric acid: 7.2 mg/dL (normal < 7.2), 2.
Total cholesterol: 202 mg/dL (normal < 200), 3.
Ferritin: 587 ng/mL (normal 22-322).
The first two items are only slightly above the normal range, but the third item is significantly elevated.
Should I be particularly concerned about this? I asked the physician who conducted the health check, and she said that this mainly assesses anemia, and the elevated level is not a concern.
If I am particularly worried, I can retest in four months.
Is this statement correct? I did some research online, and I found that high ferritin levels could also indicate chronic inflammation or other serious diseases, including cancer, so I am still a bit worried and would like to consult with you.
By the way, I have not received any blood transfusions or taken supplements this year, but due to gastroesophageal reflux, I have taken quite a few gastrointestinal-related medications.
My diet mainly consists of eggs, chicken, and vegetables (with reduced starch).

Mr. Wang, 30~39 year old female. Ask Date: 2020/10/14

Dr. Wu Zongying reply Family Medicine


Ferritin is a molecule that combines trivalent iron (Fe3+) with apoferritin, serving as a storage form of iron in the body, which can be utilized by hematopoietic cells for hemoglobin synthesis.
An increase in ferritin levels can be attributed to various causes, including inflammation (such as osteomyelitis, chronic urethritis, rheumatoid arthritis, systemic lupus erythematosus, burns, and pulmonary infections), as well as specific acute and chronic hepatocellular diseases (such as alcoholic or inflammatory liver disease), among others.
Further advanced testing is required for confirmation.

Reply Date: 2020/10/14

More Info


High ferritin levels can indeed be a cause for concern, and your inquiry about the implications of your recent lab results is very valid. Ferritin is a protein that stores iron in the body, and its levels can reflect both iron stores and the presence of inflammation or other underlying health issues.


Understanding Ferritin Levels
1. Normal Range and Interpretation: The normal range for ferritin typically falls between 22-322 ng/ml, depending on the laboratory. Your level of 587 ng/ml is significantly elevated, which warrants further investigation. While ferritin is often associated with iron levels, it is also an acute phase reactant, meaning that it can increase in response to inflammation, infection, liver disease, and certain malignancies.

2. Causes of Elevated Ferritin: Elevated ferritin can be caused by several factors:
- Iron Overload: Conditions such as hemochromatosis can lead to excessive iron accumulation in the body.

- Chronic Inflammation: Conditions like rheumatoid arthritis, lupus, or chronic infections can cause ferritin levels to rise.

- Liver Disease: Liver conditions can also affect ferritin levels.

- Malignancies: Certain cancers can lead to increased ferritin levels as well.

3. Your Specific Case: Given that you mentioned you have not received any blood transfusions or iron supplements, the elevated ferritin could be indicative of an underlying condition. Your history of gastroesophageal reflux disease (GERD) and the medications you are taking could also play a role in your overall health and iron metabolism.


Next Steps
1. Follow-Up Testing: It is prudent to follow the advice of your healthcare provider and consider retesting your ferritin levels in a few months. However, if you have any symptoms such as fatigue, unexplained weight loss, or any other concerning signs, you should seek further evaluation sooner.

2. Additional Tests: Depending on your clinical picture, your doctor may recommend additional tests such as:
- Complete Blood Count (CBC): To check for anemia or other blood disorders.

- Liver Function Tests: To assess liver health.

- Inflammatory Markers: Such as C-reactive protein (CRP) to evaluate for inflammation.

- Iron Studies: Including serum iron, total iron-binding capacity (TIBC), and transferrin saturation to better understand your iron metabolism.

3. Lifestyle Considerations: While you are managing your diet with a focus on vegetables and lean proteins, it may be beneficial to avoid excessive iron-rich foods (like red meat) until your levels are clarified. Additionally, managing any underlying conditions, such as GERD, may also help improve your overall health.


Conclusion
In summary, while your healthcare provider's reassurance is valuable, it is essential to remain vigilant about elevated ferritin levels. The potential for underlying conditions necessitates a thorough evaluation. Regular follow-ups and appropriate testing will help ensure that any significant health issues are identified and managed promptly. If you have further concerns or develop new symptoms, do not hesitate to reach out to your healthcare provider for a more immediate assessment.

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