Medication Safety During Breastfeeding: Concerns for Infants - Pediatrics

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Breastfeeding Issues: Medication Safety


Hello, my child is currently 6 months old.
However, during a recent check-up, it was found that he has a sarcoma and requires steroid treatment.
The doctor has prescribed Prednisolone 5 mg, 8 tablets (40 mg) to be taken after meals once a day, and 1 tablet of TAKEPRON 30 mg before meals to prevent gastric ulcers.
I would like to know if breastfeeding while taking these medications will affect my baby.

Miffy, 30~39 year old female. Ask Date: 2022/01/21

Dr. Xiao Kaiwen reply Pediatrics


According to the inquiry on the breastfeeding medication website, the effects of these two medications on infants through breastfeeding are classified as "cannot rule out adverse effects." Therefore, it is recommended to suspend breastfeeding while taking these medications.

Reply Date: 2022/01/21

More Info


When it comes to medication safety during breastfeeding, it is crucial to consider the potential effects of the drugs on the infant. In your case, your 6-month-old child is being exposed to Prednisolone and TAKEPRON (Pantoprazole), which raises valid concerns regarding their safety during breastfeeding.

Prednisolone is a corticosteroid that is often prescribed to reduce inflammation and suppress the immune system. While corticosteroids can pass into breast milk, studies have shown that the levels are generally low and are unlikely to cause significant adverse effects in breastfed infants. The American Academy of Pediatrics classifies Prednisolone as a medication that is usually compatible with breastfeeding. However, it is essential to monitor your infant for any signs of side effects, such as changes in behavior, appetite, or growth patterns.
The recommended practice is to take the medication immediately after breastfeeding or just before the infant's longest sleep period. This timing can help minimize the infant's exposure to the medication through breast milk. Since you are administering 40 mg of Prednisolone daily, it is advisable to discuss with your healthcare provider whether this dosage is appropriate for your condition and if any adjustments are necessary.

TAKEPRON (Pantoprazole) is a proton pump inhibitor (PPI) used to prevent gastric ulcers and manage acid-related disorders. Similar to Prednisolone, Pantoprazole is also considered safe during breastfeeding. The amount that passes into breast milk is minimal, and it is not expected to harm the infant. However, as with any medication, it is prudent to monitor your child for any unusual symptoms.

In summary, both Prednisolone and TAKEPRON are generally regarded as safe for use during breastfeeding. However, it is crucial to maintain open communication with your healthcare provider. They can provide personalized advice based on your specific medical history and the health of your infant.
Additionally, it is important to consider the following points:
1. Monitoring: Keep an eye on your infant for any signs of adverse reactions, such as irritability, feeding difficulties, or unusual changes in behavior. If you notice anything concerning, consult your pediatrician promptly.

2. Dosage: Ensure that the dosages prescribed are appropriate for your condition. If you have concerns about the amount of medication you are taking, discuss this with your doctor.

3. Alternative Treatments: If you are worried about the effects of these medications on your infant, inquire about alternative treatments that may be safer or more effective for your condition.

4. Consultation: Regularly consult with both your prescribing physician and your pediatrician to ensure that both your health and your infant's health are being adequately managed.

In conclusion, while the medications you are taking are generally considered safe during breastfeeding, it is essential to remain vigilant and proactive in monitoring your infant's health and maintaining communication with your healthcare providers.

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