Missed Period: Pregnancy Concerns or Vaccine Side Effects? - Obstetrics and Gynecology

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Delayed menstruation and pregnancy testing issues?


In the past three months, the menstrual cycles were from November 11 to November 17, December 14 to December 20, and January 13 to January 18.
During this time, unprotected intercourse occurred on January 29, February 3, and February 6.
After receiving the third dose of the Moderna vaccine on February 9, the menstrual period has not yet arrived.
Is there a possibility of pregnancy, or could this be a side effect of the vaccine? When would be the best time to take a pregnancy test? Thank you, doctor, for taking the time to respond.

Yu, 30~39 year old female. Ask Date: 2022/02/21

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, a pregnancy test can determine if you are pregnant.
Wishing you good health.

Reply Date: 2022/02/21

More Info


When it comes to missed periods, especially after receiving a vaccine like Moderna, there are several factors to consider regarding potential pregnancy and vaccine side effects.
Firstly, it’s important to understand that missed periods can occur for a variety of reasons, including hormonal changes, stress, illness, and, of course, pregnancy. Given that you had unprotected sexual intercourse on several occasions before your missed period, there is indeed a possibility of pregnancy. The timing of your menstrual cycle and the ovulation window plays a crucial role here. If you had unprotected sex during your fertile window, which is typically a few days before and after ovulation, there is a chance that you could be pregnant.

Regarding the Moderna vaccine, while some individuals report changes in their menstrual cycle following vaccination, these changes are generally temporary. Research has indicated that vaccines can cause mild immune responses, which may lead to temporary hormonal fluctuations. However, there is no substantial evidence to suggest that the vaccine directly causes missed periods or long-term menstrual irregularities. The CDC and other health organizations have noted that any changes in menstrual cycles post-vaccination are typically short-lived and resolve on their own.

To determine whether you are pregnant, it is advisable to take a home pregnancy test. These tests are most accurate when taken after a missed period, as they measure the hormone hCG (human chorionic gonadotropin), which is produced after a fertilized egg implants in the uterus. Since your period is already late, you should be able to get a reliable result now. If the test is positive, it is important to follow up with a healthcare provider for further evaluation and prenatal care.

If the test is negative and your period still does not arrive, it may be wise to consult a healthcare professional. They can help determine if there are other underlying issues contributing to your missed period, such as hormonal imbalances or stress-related factors.

In summary, while there is a possibility of pregnancy given your sexual activity, the missed period could also be a result of the vaccine or other factors. Taking a home pregnancy test now would be the best course of action to clarify your situation. If you have further concerns or if your period does not return, seeking medical advice would be prudent to ensure your overall health and well-being.

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