Drug Side Effects in Cardiovascular Treatments: A Patient's Journey - Cardiology

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Drug side effects


I have atrial fibrillation, arrhythmia, and cardiovascular disease.
Six months ago, my doctor continued my prescription for "Pradaxa" and increased "Dabigatran." After taking it for about a month, blood tests revealed that my TSH level was 44, and my kidney function declined from 60% to 45%.
The doctor switched my medication from Dabigatran to "Metoprolol" and referred me to an endocrinologist.
I later learned that I have hypothyroidism and was informed that I might need to take thyroid medication for life due to potential thyroid damage.
A family physician had previously warned me about the serious side effects of Dabigatran (permanent lung fibrosis and thyroid dysfunction) and advised me to ask my doctor to change my medication.
Two days ago, I asked my cardiologist why he didn't prescribe Metoprolol directly, which led to my lifelong need for thyroid medication and worsened my kidney function to stage 3B.
The doctor replied, "The National Health Insurance Administration requires that Dabigatran be used first before prescribing Metoprolol." I would like to inquire if the National Health Insurance Administration has such a regulation.

Leimon, 60~69 year old female. Ask Date: 2022/02/26

Dr. Li Han reply Cardiology


Hello, regarding your inquiry about "Pradaxa" and "Xarelto" due to paroxysmal atrial fibrillation, and the subsequent change to "Praxbind" after the diagnosis of "hypothyroidism" and "suspected kidney damage"; clinical trials indicate that "Praxbind" may also lead to severe liver injury and serious cardiovascular side effects, as well as a potential risk of lung injury.
The risks associated with this medication are not less than those of "Xarelto," thus its use is also restricted.
Generally, it should be prescribed after evaluation by a specialist when no more appropriate antiarrhythmic medications are available.
The physician's intentions are well-meaning, and we appreciate your understanding from Changhua Hospital, Ministry of Health and Welfare.

Reply Date: 2022/02/26

More Info


Understanding drug side effects in cardiovascular treatments is crucial for patients, especially those dealing with complex conditions like atrial fibrillation, arrhythmias, and other cardiovascular diseases. Your experience highlights the challenges many patients face when navigating medication regimens and the potential side effects that can arise.

In your case, it appears that you were prescribed "普栓達" (Prasugrel) and "藏得樂" (Dronedarone) to manage your cardiovascular condition. After a month of treatment, you experienced significant changes in your health, including a dramatic increase in your TSH levels and a decline in kidney function. These changes prompted your physician to switch your medication to "脈泰克" (Sotalol) and refer you to a metabolic specialist, where you were diagnosed with hypothyroidism, potentially linked to the previous medication.

The side effects you experienced are not uncommon with Dronedarone, which has been associated with thyroid dysfunction and other serious side effects, including pulmonary fibrosis. The concern about long-term use of such medications is valid, especially when they can lead to conditions requiring lifelong management, such as hypothyroidism. It’s essential to communicate openly with your healthcare providers about any side effects you experience, as this can lead to timely adjustments in your treatment plan.

Regarding your question about the regulations set by the health insurance bureau, it is important to note that healthcare systems often have protocols in place for prescribing certain medications. In many cases, physicians are required to follow specific guidelines or step therapy protocols, which may dictate that certain medications must be tried before others can be prescribed. This is often done to ensure that patients receive the most cost-effective treatment first, but it can sometimes lead to complications if the initial medication causes adverse effects.

If you feel that your treatment plan is not adequately addressing your health needs or if you have concerns about the side effects of your medications, it is essential to advocate for yourself. Here are some steps you can take:
1. Seek a Second Opinion: If you are uncomfortable with the current treatment plan or feel that your concerns are not being adequately addressed, consider seeking a second opinion from another cardiologist or a specialist in pharmacology.

2. Discuss Alternatives: Have an open discussion with your healthcare provider about alternative medications that may be available for your condition. There may be other options that do not carry the same risk of severe side effects.

3. Monitor Your Health: Keep a detailed record of any symptoms or side effects you experience while on medication. This information can be invaluable during consultations with your healthcare providers.

4. Educate Yourself: Understanding your medications and their potential side effects can empower you to make informed decisions about your health. Resources such as the FDA website or reputable medical websites can provide valuable information.

5. Patient Advocacy: If you believe that the regulations are not in your best interest, consider reaching out to patient advocacy groups that can provide support and guidance on navigating the healthcare system.

In conclusion, managing cardiovascular diseases often involves a careful balance between the benefits of medication and the potential for side effects. It is crucial to maintain open communication with your healthcare providers, advocate for your health, and seek alternatives if necessary. Your health is paramount, and you deserve a treatment plan that effectively manages your condition without compromising your overall well-being.

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