Abnormal Pap Smear Results: What You Need to Know - Obstetrics and Gynecology

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Abnormal cervical smear?


Hello Doctor, I previously had a Pap smear, and the report indicated an abnormal cervical smear result of 4: Atypical Squamous Cells of Undetermined Significance (ASC-US).
Although today is the second day of my menstrual period, I still went to the hospital to see the doctor.
The doctor immediately recommended a colposcopy with biopsy, and two large lesions were biopsied.
After returning home, I have some concerning questions I would like to ask you.

1.
I found in the literature that ASC-US can have different management options, such as follow-up Pap smears or HPV testing, and only proceeding to colposcopy if there are abnormalities.
However, the doctor insisted on performing the colposcopy and biopsy today despite knowing I was menstruating, and scheduled a follow-up in a week to discuss the results.
Does this urgency indicate that my condition is quite serious?
2.
My previous Pap smear results were normal, and this time it is ASC-US.
What is the likelihood that the biopsy results could indicate carcinoma in situ or even invasive cancer? What are the more common conditions that could be found instead?
3.
In cases of abnormal Pap smears leading to colposcopy, do doctors typically perform biopsies, and is it common to take two samples at once?
Thank you for your guidance on these matters.

A Tao, 50~59 year old female. Ask Date: 2022/03/01

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, I have already responded to your question earlier.
Wishing you good health.

Reply Date: 2022/03/01

More Info


Understanding abnormal Pap smear results can be a source of anxiety for many women, especially when faced with terms like Atypical Squamous Cells of Undetermined Significance (ASC-US). Here’s a comprehensive overview of what ASC-US means, the implications of your recent findings, and the next steps in management.

1. What is ASC-US?
ASC-US is a category in Pap smear results that indicates the presence of atypical squamous cells, but these changes are not definitively indicative of cancer. It is a common finding and can arise from various causes, including inflammation, infection (such as HPV), or hormonal changes. The key point is that ASC-US does not mean you have cancer; it simply requires further evaluation to determine the cause of the atypical cells.

2. Why the urgency for a colposcopy?
Your doctor’s decision to perform a colposcopy and biopsy, even during your menstrual period, suggests a proactive approach to ensure that any potential issues are addressed promptly. While it may feel alarming, this urgency does not necessarily indicate that your condition is severe. Colposcopy allows for a closer examination of the cervix and can help identify any areas that may require further investigation. The biopsy taken during this procedure will provide critical information about the nature of the abnormal cells.

3. Risk of cancer with ASC-US:
The likelihood of finding cancer (either in situ or invasive) in patients with ASC-US is relatively low. Studies suggest that the risk of high-grade lesions (which could lead to cervical cancer) is higher in women with ASC-US who are also HPV positive. The majority of women with ASC-US will not have significant pathology. However, the presence of ASC-US does warrant further investigation to rule out any serious conditions.

4. Colposcopy and biopsy process:
It is standard practice for doctors to perform biopsies during a colposcopy when abnormal cells are detected. The number of biopsies taken can vary based on the findings during the examination. In your case, the doctor took two biopsies, which is not uncommon if there are multiple areas of concern. The biopsies will be analyzed to determine if there are any precancerous changes or cancer present.

5. Next steps after biopsy:
After the biopsy, you will typically wait for the results, which can take about a week. If the results show no significant abnormalities, your doctor may recommend routine follow-up Pap smears and HPV testing. If the results indicate high-grade lesions or cancer, further treatment options will be discussed, which may include more extensive surgical procedures.

6. Managing anxiety and concerns:
It’s natural to feel anxious after receiving abnormal results and undergoing further testing. It’s important to communicate openly with your healthcare provider about your concerns. They can provide reassurance and clarify any uncertainties you may have regarding the results and the implications for your health.

In conclusion, while receiving an ASC-US result can be concerning, it is essential to remember that it is a common finding and does not automatically indicate cancer. The follow-up procedures, including colposcopy and biopsy, are critical steps in ensuring your health and addressing any potential issues early on. Stay informed, and don’t hesitate to reach out to your healthcare provider with any questions or concerns as you await your results.

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