Impact of Birth Control Pills on Cholesterol Levels: What You Need to Know - Obstetrics and Gynecology

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Birth control pills and cholesterol?


Dear Director: I have been taking oral contraceptives and menstrual regulation medication for about three months.
Recently, my blood test results showed elevated total cholesterol levels.
The total cholesterol is 385 mg/dL, low-density lipoprotein (LDL) cholesterol is 296 mg/dL, free thyroxine (FT4) is <0.42 ng/dL, and thyroid-stimulating hormone (TSH) is 59.877 µIU/mL.
I have a history of thyroid abnormalities.
Could the elevated cholesterol levels be primarily caused by the oral contraceptives? Should I stop taking the oral contraceptives, as I need to prevent pregnancy? Or should I prioritize addressing the thyroid function issues first? Thank you, Director.

Wenwen, 30~39 year old female. Ask Date: 2022/03/01

Dr. Cao Guotao reply Obstetrics and Gynecology


Hello, the two are not closely related, and you can continue taking the contraceptive pill.
Wishing you good health.

Reply Date: 2022/03/01

More Info


The relationship between birth control pills and cholesterol levels is a significant concern for many women, especially those with pre-existing conditions such as thyroid disorders. Birth control pills, particularly those containing estrogen, can influence lipid metabolism and may lead to changes in cholesterol levels.
When you take oral contraceptives, they can affect the liver's production of lipoproteins, which are responsible for transporting cholesterol in the bloodstream. Estrogen, a key component in many birth control pills, tends to increase levels of high-density lipoprotein (HDL) cholesterol, often referred to as "good" cholesterol. However, it can also lead to an increase in low-density lipoprotein (LDL) cholesterol, known as "bad" cholesterol, and triglycerides in some women. This is particularly relevant for women who may already have a predisposition to high cholesterol or other lipid abnormalities.

In your case, with total cholesterol at 385 mg/dL and LDL at 296 mg/dL, these levels are significantly elevated. It is essential to consider that while birth control pills may contribute to these changes, other factors such as your thyroid condition could also play a crucial role. Thyroid disorders can significantly impact metabolism, including lipid metabolism, and can lead to dyslipidemia (abnormal lipid levels).
Given your elevated cholesterol levels, it is advisable to consult with your healthcare provider to evaluate the potential causes of your dyslipidemia. They may recommend the following steps:
1. Thyroid Function Assessment: Since you have a history of thyroid issues, it is crucial to ensure that your thyroid hormone levels are well-regulated. An underactive thyroid (hypothyroidism) can lead to increased cholesterol levels, and managing this condition may help normalize your lipid profile.

2. Review of Birth Control Options: If your healthcare provider determines that the oral contraceptive is significantly contributing to your elevated cholesterol levels, they may suggest alternative forms of contraception that have a lower impact on lipid levels. Options such as progestin-only pills or non-hormonal methods may be considered.

3. Lifestyle Modifications: Regardless of the cause, adopting a heart-healthy lifestyle can help manage cholesterol levels. This includes a balanced diet low in saturated fats and trans fats, regular physical activity, maintaining a healthy weight, and avoiding smoking.

4. Regular Monitoring: Continuous monitoring of your cholesterol levels and thyroid function is essential. Your healthcare provider may recommend follow-up blood tests to track changes and adjust treatment as necessary.

5. Medication Consideration: If lifestyle changes and managing your thyroid condition do not adequately address your cholesterol levels, your healthcare provider may discuss the possibility of cholesterol-lowering medications.

In conclusion, while birth control pills can influence cholesterol levels, it is essential to consider your overall health, including thyroid function. Stopping the pill without an alternative contraceptive method may not be advisable if you need to prevent pregnancy. Therefore, a thorough discussion with your healthcare provider is crucial to determine the best course of action tailored to your specific health needs.

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