Protecting Your Liver and Kidneys While Taking Long-Term Medications - Gastroenterology and Hepatology

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How to protect the liver and kidneys during long-term medication use?


Hello Doctor: I am a 19-year-old patient with ankylosing spondylitis, and I have been experiencing symptoms for over two years.
For the past year, I have been managing my condition with Celecoxib (a non-steroidal anti-inflammatory drug).
During my follow-up visits, my ALT and creatinine levels have been normal.
My primary physician has advised that I will need to continue taking this medication long-term, as the medication's information leaflet indicates potential liver and kidney damage with prolonged use.
However, I cannot stop taking it.
I would like to ask the doctor what additional measures I can take while on this medication to minimize potential damage to my liver and kidneys in the future.

Zheng, 10~19 year old female. Ask Date: 2022/03/18

Dr. Chen Shidian reply Gastroenterology and Hepatology


Maintain a normal diet, avoid using unverified remedies, and have regular blood tests.

Reply Date: 2022/03/18

More Info


When it comes to protecting your liver and kidneys while taking long-term medications, especially non-steroidal anti-inflammatory drugs (NSAIDs) like Celebrex (the brand name for celecoxib), there are several strategies you can adopt to minimize potential damage. As a 19-year-old patient with ankylosing spondylitis, it’s crucial to balance effective pain management with the health of your liver and kidneys.


1. Regular Monitoring
The first step in safeguarding your liver and kidneys is to maintain regular check-ups with your healthcare provider. Since you are already having your ALT (alanine aminotransferase) and creatinine levels monitored, continue this practice. Regular blood tests can help detect any early signs of liver or kidney dysfunction, allowing for timely intervention.


2. Maintain a Healthy Diet
A balanced diet plays a vital role in liver and kidney health. Focus on:
- Hydration: Drink plenty of water to help your kidneys filter waste effectively. Aim for at least 8-10 glasses a day, unless otherwise advised by your doctor.

- Nutrient-Rich Foods: Incorporate fruits, vegetables, whole grains, and lean proteins into your diet. Foods rich in antioxidants, such as berries and leafy greens, can help reduce oxidative stress on your organs.

- Limit Alcohol: Alcohol can exacerbate liver damage, especially when combined with medications. It’s best to avoid alcohol altogether or consume it in moderation, as advised by your healthcare provider.


3. Avoid Over-the-Counter Medications
Be cautious with over-the-counter medications, especially other NSAIDs or acetaminophen (Tylenol), as they can increase the risk of liver and kidney damage when taken alongside your prescribed medications. Always consult your doctor before adding any new medications or supplements to your regimen.


4. Lifestyle Modifications
Adopting a healthy lifestyle can significantly impact your overall health:
- Exercise Regularly: Engage in regular physical activity, which can help maintain a healthy weight and improve circulation, benefiting both liver and kidney function.

- Quit Smoking: If you smoke, seek help to quit. Smoking can worsen the effects of medications on your liver and kidneys.


5. Medication Management
Discuss with your doctor the possibility of adjusting your medication regimen. If you are on long-term NSAIDs, your doctor might consider:
- Alternative Medications: Depending on your condition, there may be alternative treatments that pose less risk to your liver and kidneys.

- Lower Doses: If possible, using the lowest effective dose of your medication can help minimize potential side effects.


6. Supplements and Herbal Remedies
While some people consider supplements to support liver and kidney health, it’s essential to approach this cautiously. Some herbal remedies can interact with medications and potentially cause harm. Always discuss any supplements with your healthcare provider before starting them.


7. Educate Yourself
Stay informed about your condition and the medications you are taking. Understanding the potential side effects and risks associated with long-term NSAID use can empower you to make informed decisions about your health.


Conclusion
While long-term use of medications like NSAIDs is sometimes necessary for managing chronic conditions such as ankylosing spondylitis, taking proactive steps can help protect your liver and kidneys. Regular monitoring, a healthy diet, lifestyle modifications, and open communication with your healthcare provider are key components in minimizing the risks associated with long-term medication use. Always prioritize your health and well-being by staying engaged in your treatment plan and advocating for your needs.

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