Long-Term Medication Effects on Children's Liver and Kidney Health - Pediatrics

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Will long-term medication use have an impact?


Hello, doctor.
My daughter is five years old and has a history of asthma, nasal allergies, and persistent runny nose.
She has been coughing with phlegm, so she has been taking cold medication.
Recently, she has had issues with fluid in her ears and has been prescribed antibiotics.
I would like to ask if taking these medications for four months could have any impact on her liver or kidneys.
Thank you.

Ms. Li, 30~39 year old female. Ask Date: 2011/03/21

Dr. Xiao Kaiwen reply Pediatrics


The key point is that it is safe to follow prescriptions issued by experienced and specialized pediatric allergists and immunologists, as they will not harm the body.
In fact, excessive concern and failure to cooperate with a professional physician can worsen the situation (for instance, if there is a bacterial infection, antibiotics are necessary).
This can lead to a deterioration of allergic conditions, as a child's constitution can change, but if they have already reached puberty, it may remain the same, potentially resulting in a lifelong allergic disposition.
Additionally, stopping antibiotics prematurely before completing the prescribed course can lead to antibiotic resistance issues.

Reply Date: 2011/03/21

More Info


When it comes to the long-term use of medications in children, particularly for conditions like asthma, allergies, and respiratory infections, it is essential to consider both the benefits and potential risks associated with prolonged medication use. Your concern about the effects of long-term medication on your daughter's liver and kidney health is valid, especially given her age and the medications she has been prescribed.

First and foremost, it is crucial to understand that medications prescribed by a qualified pediatrician or a specialist in pediatric allergy and immunology are generally safe when used as directed. These healthcare professionals take into account the child's overall health, medical history, and specific conditions when prescribing medications. In your daughter's case, the medications she is taking for asthma and allergies are likely aimed at managing her symptoms effectively.

Regarding the specific medications, common treatments for asthma and allergies, such as antihistamines and bronchodilators, are typically well-tolerated in children. However, some medications can have side effects, particularly when used over an extended period. For instance, corticosteroids, which are sometimes prescribed for asthma, can have effects on growth and metabolism if used long-term. It is essential to monitor for any potential side effects, including changes in appetite, weight, or mood.

Antibiotics, which your daughter has been taking for ear infections, are also a concern when used long-term. While antibiotics are necessary for treating bacterial infections, their overuse can lead to antibiotic resistance and may disrupt the natural balance of bacteria in the gut. This disruption can lead to gastrointestinal issues, such as diarrhea or bloating, which you mentioned in your question. It is important to complete the full course of antibiotics as prescribed to effectively treat the infection and reduce the risk of resistance.

In terms of liver and kidney health, most medications prescribed for asthma and allergies do not have significant adverse effects on these organs when used appropriately. However, it is always wise to have regular check-ups with your child's healthcare provider, who may recommend periodic blood tests to monitor liver and kidney function, especially if your daughter is on multiple medications or has underlying health issues.

If you have concerns about the duration of medication use, it is advisable to discuss them with your child's doctor. They can evaluate her current treatment plan and determine if any adjustments are necessary. In some cases, they may suggest alternative therapies or lifestyle changes that can help manage her symptoms without relying solely on medications.

In summary, while long-term medication use in children can raise concerns about potential effects on liver and kidney health, these risks are generally manageable under the guidance of a healthcare professional. Regular monitoring, open communication with your child's doctor, and adherence to prescribed treatments are key to ensuring her health and well-being. If you notice any unusual symptoms or side effects, do not hesitate to reach out to her healthcare provider for further evaluation and guidance.

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