Long-Term Medication Use: Potential Side Effects and Kidney Health Concerns

Q: Long-Term Medication Use: Potential Side Effects and Kidney Health Concerns

Hello： The medication you are taking may have adverse effects on your liver and kidneys in the long term. <br>Considering your age, it may not be necessary for you to take medication long-term unless there are any congenital defects. <br>I recommend that you consult with the phys

What are the side effects of long-term medication use on the body?

Hello Doctor: I have been experiencing urinary issues (prolonged urge to urinate, weak urine flow, frequent urination, and nocturia).
I have been intermittently taking Detrusitol SR 4mg for about six months, but recently switched to Buwecon Tab 0.125mg, Doxaben Tab 2mg, Cyclin Cap 100mg, and have also been dealing with insomnia, for which I am taking Deanxit 0.5mg and Kalma 1mg.
I would like to know if taking these medications frequently could harm my kidneys or if there are any side effects on my body.
I have been confused about taking Western medicine since childhood.

Xiao Xiao, 20~29 year old female. Ask Date: 2007/02/21

Dr. Cai Jueren reply Family Medicine

Hello: The medication you are taking may have adverse effects on your liver and kidneys in the long term.
Considering your age, it may not be necessary for you to take medication long-term unless there are any congenital defects.
I recommend that you consult with the physician who prescribed your medication to determine if long-term use is necessary, especially for antibiotics (Cyclin).
Thank you for your inquiry, and I hope the above information addresses your concerns.
Dr.
Tsai Jue-Ren, Hualien Hospital.

Reply Date: 2007/02/21

More Info

Long-term medication use can indeed lead to various side effects, especially when multiple medications are involved. In your case, you have been taking several medications for urinary issues, sleep disturbances, and other conditions. Each of these medications can have specific side effects, and their interactions can also pose additional risks.

Potential Side Effects of Your Medications
1. Detrusitol (Tolterodine): This medication is used to treat overactive bladder. Common side effects include dry mouth, constipation, dizziness, and blurred vision. Long-term use may lead to urinary retention or cognitive impairment, especially in older adults.

2. Buwecon (Buprenorphine): This medication is primarily used for pain management and can cause sedation, dizziness, and constipation. It may also have a risk of dependency if used long-term.

3. Doxaben (Doxazosin): This medication is an alpha-blocker used for hypertension and urinary symptoms related to benign prostatic hyperplasia. Side effects can include dizziness, fatigue, and orthostatic hypotension (a drop in blood pressure when standing up).

4. Cyclin (Tetracycline): As an antibiotic, long-term use can lead to antibiotic resistance and may affect gut flora. It can also cause photosensitivity and gastrointestinal upset.

5. Deanxit (Flupentixol and Melitracen): This combination is used for anxiety and depression. Side effects may include sedation, weight gain, and potential withdrawal symptoms if discontinued abruptly.

6. Kalma (Clonazepam): This benzodiazepine is used for anxiety and sleep disorders. Long-term use can lead to tolerance, dependence, and withdrawal symptoms. It may also impair cognitive function and coordination.

Kidney Health Concerns
Regarding your specific concern about kidney health, it is essential to consider the following:
- Renal Function: Some medications can have nephrotoxic effects, especially if taken in high doses or for extended periods. While the medications you listed are not primarily known for causing direct kidney damage, certain factors such as dehydration, existing kidney issues, or concurrent use of other nephrotoxic drugs can increase the risk.

- Monitoring: If you have any pre-existing kidney conditions or if you are at risk (e.g., due to diabetes or hypertension), it is advisable to have regular kidney function tests (like serum creatinine and eGFR) to monitor your renal health. This is particularly important if you are on medications that can affect kidney function.

- Polypharmacy Risks: Taking multiple medications increases the risk of drug interactions, which can exacerbate side effects or lead to new health issues. It is crucial to have a healthcare provider regularly review your medications to ensure they are still necessary and to adjust dosages as needed.

Recommendations
1. Consult Your Doctor: It is vital to discuss your concerns with your healthcare provider. They can evaluate the necessity of each medication, consider potential alternatives, and monitor for side effects.

2. Lifestyle Modifications: Alongside medication, lifestyle changes such as maintaining a healthy diet, staying hydrated, and managing stress can significantly impact your overall health and may help alleviate some of your symptoms.

3. Regular Check-ups: Schedule regular follow-ups to assess your kidney function and overall health. This will help catch any potential issues early and allow for timely intervention.

In conclusion, while long-term medication use can lead to various side effects, including potential impacts on kidney health, careful monitoring and regular consultations with your healthcare provider can help mitigate these risks. Always prioritize open communication with your doctor regarding any new symptoms or concerns you may have.

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