Sinzac: Managing Sleep Disorders and Side Effects - Psychiatry

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Inquiry about circadian rhythm disruption and side effects of Sinzac?


Hello, Doctor.
Due to the heavy pressure from my coursework, my circadian rhythm has been disrupted over the past year.
I often find it difficult to fall asleep until 5 AM and need to sleep until 2 PM to feel rested.
If I have obligations during the day, I feel like I've pulled an all-nighter, and then at night, I become overly fatigued and fall asleep, but it feels more like a nap, causing me to wake up at 1 AM feeling quite alert.
After consulting with a therapist, I was advised to see a psychiatrist, but I have some questions about the medication Sinzac (Silenor) that was prescribed.
At the time, I didn’t ask about the medication because I was unsure what it was:
1.
This medication seems to be one that prevents serotonin depletion.
The doctor advised taking it regularly during the day; is this to help maintain alertness and prevent drowsiness during the day?
2.
The medication has been prescribed for three weeks.
I would like to know if, with proper adherence to the medication and improvements in my lifestyle, it is possible to completely discontinue the medication after three weeks?
3.
There is a warning associated with this medication regarding potential damage to sexual function.
Is this damage irreversible? If I only take the medication for three weeks, will these side effects persist after discontinuation?
4.
This medication also appears to have antidepressant properties.
Given that I experience significant stress in my daily life, will this medication also help improve my mood and make me and those around me feel happier?
Thank you very much for taking the time to answer my questions.
I am quite apprehensive about medications that alter neurotransmitters, as I worry about drastic changes in my mood, potential harm to my reproductive capabilities and cognitive function, or the possibility of dependency.
I am even considering whether I should avoid taking medication altogether.
Wishing you good health.

Li Jiatou, 20~29 year old female. Ask Date: 2022/03/18

Dr. Xue Gengming reply Psychiatry


It is recommended that you consult with a mental health specialist to see if any relevant examinations are necessary.
Thank you, and wishing you good health!

Reply Date: 2022/03/18

More Info


Sinzac (Sulpiride) is a medication primarily used to treat various psychiatric conditions, including anxiety and depression. It is classified as an atypical antipsychotic and works by modulating the levels of neurotransmitters in the brain, particularly serotonin and dopamine. Your concerns regarding the use of Sinzac, especially in relation to sleep disorders and its side effects, are valid and warrant a detailed discussion.

1. Mechanism and Timing of Administration: Sinzac is indeed known to influence serotonin levels, which can help stabilize mood and alleviate anxiety. The recommendation to take it during the day is likely aimed at maximizing its therapeutic effects while minimizing sedation. By taking it in the morning or early afternoon, the medication can help improve your mood and energy levels throughout the day, potentially making it easier to engage in daily activities. This timing can also help prevent the medication from interfering with your nighttime sleep, as some individuals may experience increased alertness or wakefulness after taking it.

2. Duration of Treatment: Regarding your question about stopping the medication after three weeks, it is essential to understand that while some individuals may notice improvements in their sleep and mood within this timeframe, others may require a longer duration of treatment to achieve optimal results. It is crucial to follow your healthcare provider's guidance on medication duration and not to discontinue it abruptly without consulting them. Gradual tapering may be necessary to avoid withdrawal symptoms or a return of anxiety and sleep disturbances.

3. Sexual Side Effects: Concerns about sexual dysfunction are common with many psychiatric medications, including Sinzac. While some individuals may experience temporary changes in sexual function, these effects are not universally permanent. If you have been on the medication for only three weeks, it is unlikely that any sexual side effects would be irreversible. However, if you do experience such side effects, it is essential to discuss them with your healthcare provider, who can help determine the best course of action, whether that involves adjusting the dosage or considering alternative treatments.

4. Impact on Mood and Relationships: Sinzac may have a dual effect of alleviating anxiety and improving mood, which can positively influence your interactions with others. Many patients report feeling more balanced and less overwhelmed by stressors after starting treatment. This improvement can lead to better relationships and a more enjoyable daily life. However, it is essential to monitor your emotional responses closely and communicate any significant changes to your healthcare provider.

Your apprehension about altering neurotransmitter levels is understandable, especially given the potential for side effects. It is crucial to have open discussions with your healthcare provider about your concerns, including the fear of emotional instability or cognitive impairment. They can provide reassurance and help you weigh the benefits of treatment against the risks.

In addition to medication, consider incorporating lifestyle changes that can enhance your overall well-being. Regular exercise, a balanced diet, and good sleep hygiene practices can significantly improve sleep quality and reduce anxiety. Cognitive-behavioral therapy (CBT) is another effective approach for managing anxiety and sleep disorders, which can complement the effects of medication.

In conclusion, while Sinzac can be an effective part of your treatment plan, it is essential to approach it with a comprehensive understanding and a willingness to communicate openly with your healthcare provider. Together, you can develop a strategy that addresses your sleep issues while minimizing potential side effects, ultimately leading to a healthier and more balanced life.

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