Gastric Biopsy Results: Chronic Inflammation and Its Implications

Q: Gastric Biopsy Results: Chronic Inflammation and Its Implications

Hello： Chronic inflammation is generally described as the absence of Helicobacter pylori and cancer cells. <br>Changhua Hospital cares about your health. <br>Dr. <br>Tsai An-shun.

Gastric biopsy report?

Hello, Dr.
Tsai.
My mother previously underwent gastroscopy and colonoscopy, and it was noted that she had a small ulcer in her stomach.
The gastric biopsy results were delayed, and I forgot to follow up.
Recently, I checked the report using the National Health Insurance Easy Access system (HCF) and found the following microscopic findings: "Sections show gastric mucosal tissue with chronic inflammatory cell infiltration.
There is no intestinal metaplasia.
There is no morphologic feature of malignancy in the specimen examined.
No Helicobacter bacillus is found in H&E-stained and modified Giemsa-stained sections." I would like to ask if this result is acceptable, as I found that it mentions chronic inflammation of the gastric mucosa.
Thank you, doctor.

Mr. Wang, 20~29 year old female. Ask Date: 2022/05/26

Dr. Cai Anshun reply Gastroenterology and Hepatology

Hello: Chronic inflammation is generally described as the absence of Helicobacter pylori and cancer cells.
Changhua Hospital cares about your health.
Dr.
Tsai An-shun.

Reply Date: 2022/05/26

More Info

The biopsy results you received indicate that there is chronic inflammation present in the gastric mucosal tissue, but importantly, there are no signs of intestinal metaplasia or malignancy, and Helicobacter pylori bacteria were not found. Let's break down what this means and its implications for your health.

Understanding Chronic Inflammation in the Stomach
Chronic inflammation in the stomach can arise from various causes, including long-term irritation due to factors such as:
1. Dietary Habits: Consumption of spicy foods, alcohol, and caffeine can irritate the gastric lining.

2. Medications: Nonsteroidal anti-inflammatory drugs (NSAIDs) and certain other medications can lead to gastric irritation.

3. Infections: While your results did not show Helicobacter pylori, this bacterium is a common cause of chronic gastritis.

4. Autoimmune Conditions: In some cases, the body's immune system may mistakenly attack the stomach lining.

Implications of Your Results
1. No Malignancy: The absence of malignancy is a positive outcome. It means that there are no cancerous changes in the tissue sampled.

2. No Intestinal Metaplasia: Intestinal metaplasia is a condition where the stomach lining changes to resemble the intestines, which can be a precursor to gastric cancer. Its absence is reassuring.

3. Chronic Inflammation: Chronic inflammation can lead to symptoms such as abdominal pain, bloating, and discomfort. It may also increase the risk of developing ulcers or other gastric conditions over time.

Treatment and Management
Given that your biopsy results indicate chronic inflammation without serious complications, the next steps typically involve:
1. Lifestyle Modifications:
- Diet: Consider adopting a bland diet that avoids irritants. Foods that are easy to digest and low in acidity can help soothe the stomach lining.

- Avoid NSAIDs: If you are taking any anti-inflammatory medications, discuss alternatives with your healthcare provider.

- Limit Alcohol and Caffeine: These substances can exacerbate gastric irritation.

2. Medications:
- Proton Pump Inhibitors (PPIs): Medications like omeprazole or esomeprazole can reduce stomach acid production, helping to alleviate symptoms and promote healing.

- Antacids: Over-the-counter antacids can provide symptomatic relief.

3. Follow-Up: Regular follow-up with your healthcare provider is essential. They may recommend periodic endoscopies to monitor the condition of your stomach lining, especially if symptoms persist.

Conclusion
In summary, while chronic inflammation in the stomach can be concerning, your biopsy results are reassuring in that they show no signs of malignancy or intestinal metaplasia. It is crucial to address the underlying causes of inflammation through lifestyle changes and possibly medication. Regular follow-ups with your healthcare provider will help ensure that any changes in your condition are monitored and managed appropriately. If you have ongoing symptoms or concerns, do not hesitate to reach out to your doctor for further evaluation and personalized treatment options.

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