Your Endoscopy Report: Chronic Inflammation Explained - Gastroenterology and Hepatology

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Gastrointestinal Endoscopy Report Interpretation


The report you received indicates the following:
The endoscopic biopsy was taken from the terminal ileum, which is the last part of the small intestine.
The findings show chronic inflammation in the tissue sample.

The specimen consists of two small fragments of tissue, each measuring approximately 0.3 x 0.2 x 0.2 cm, which were preserved in formalin for examination.

Grossly, the tissue appears gray and soft.
Upon microscopic examination, the sections reveal a nonspecific chronic inflammatory response characterized by an infiltration of mixed inflammatory cells within the edematous lamina propria, which is the layer of connective tissue beneath the epithelium of the intestine.
In summary, the biopsy results suggest that there is ongoing chronic inflammation in the terminal ileum, but further clinical correlation and evaluation by your physician are necessary to determine the underlying cause and appropriate management.

Jj, 20~29 year old female. Ask Date: 2022/12/08

Dr. Lin Minghui reply Gastroenterology and Hepatology


Hello: Regarding the report of the painless gastrointestinal endoscopy.
The patient is still not fully alert after waking from anesthesia.
It is recommended to consult with the outpatient clinic along with the imaging and biopsy pathology reports for a clearer explanation from the physician.
The pathology report indicates that the biopsy of the terminal ileum is diagnosed as chronic inflammation.
Wishing you good health!

Reply Date: 2022/12/08

More Info


The endoscopy report you received indicates that there is chronic inflammation in the terminal ileum, which is the last part of the small intestine. Let's break down the findings to help you understand what they mean.

1. Chronic Inflammation: This term refers to a prolonged inflammatory response that can last for months or even years. Unlike acute inflammation, which is a short-term process that usually resolves quickly, chronic inflammation can lead to tissue damage and may be associated with various underlying conditions. In your case, the report describes "nonspecific chronic inflammation," which means that while there is inflammation present, the specific cause is not identified from the biopsy. This could be due to a variety of factors, including infections, autoimmune diseases, or irritants such as certain foods or medications.

2. Microscopic Findings: The report mentions that the tissue sections show "mixed inflammatory cells in edematous lamina propria." The lamina propria is a layer of connective tissue in the intestinal wall that supports the epithelium. The presence of mixed inflammatory cells suggests that there is a diverse immune response occurring in the tissue. Edema indicates swelling, which is often a result of inflammation. This combination of findings is consistent with chronic inflammatory conditions but does not point to a specific diagnosis.

3. Possible Causes: Chronic inflammation in the terminal ileum can be associated with several conditions. One of the most common is Crohn's disease, a type of inflammatory bowel disease (IBD) that can affect any part of the gastrointestinal tract but often involves the ileum. Other potential causes could include infections, such as those caused by certain bacteria or parasites, or conditions like celiac disease or even non-specific ileitis.

4. Next Steps: Given that the report indicates chronic inflammation, it is essential to follow up with your healthcare provider for further evaluation. They may recommend additional tests, such as blood tests, imaging studies, or even further endoscopic procedures, to determine the underlying cause of the inflammation. It is also crucial to discuss your symptoms, medical history, and any other relevant factors with your doctor, as this information can help guide diagnosis and treatment.

5. Management and Treatment: Treatment for chronic inflammation in the intestine will depend on the underlying cause. If a specific condition is diagnosed, such as Crohn's disease, treatment may involve medications to reduce inflammation, dietary changes, and possibly surgery in severe cases. If the inflammation is due to an infection, antibiotics or other medications may be necessary.

In summary, your endoscopy report indicates chronic inflammation in the terminal ileum, which requires further investigation to determine the cause. It is important to have a follow-up appointment with your healthcare provider to discuss the findings and any necessary next steps. They can provide you with a clearer understanding of your condition and the best course of action moving forward.

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