Bleeding at Vaccine Injection Site in Children: What to Know - Pediatrics

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Bleeding at the vaccination site?


Hello, a 7-year and 11-month-old child experienced a large blood stain (approximately the size of a five-dollar coin) on the cotton ball at the injection site after receiving the second dose of the pediatric BNT vaccine.
This has never happened after previous vaccinations.
Could this indicate that the vaccine was injected into a blood vessel? Are there any potential side effects or increased risk of myocarditis?

Mr. Jiang, 40~49 year old female. Ask Date: 2022/07/02

Dr. Xiao Kaiwen reply Pediatrics


The current BNT COVID-19 vaccine for children aged 5-11 is administered via intramuscular injection in the deltoid muscle of the upper arm, rather than intravenously.
The depth of this intramuscular injection does not involve major blood vessels, so the theoretical risk of the vaccine being directly injected into a large vessel is very low.
I believe this phenomenon is likely due to microvascular rupture after the injection, compounded by incomplete pressure from the cotton ball applied afterward.
This should not affect the efficacy of the vaccine or increase the risk of side effects, nor does it elevate the risk of myocarditis as a side effect.

Reply Date: 2022/07/02

More Info


When a child experiences bleeding at the vaccine injection site, such as in the case of your 7-year-11-month-old after receiving the second dose of the BNT (BioNTech) vaccine, it can understandably cause concern for parents. However, it's important to understand the context and the typical outcomes associated with such occurrences.

Firstly, the BNT vaccine for children is administered intramuscularly, specifically into the deltoid muscle of the upper arm. This method is designed to ensure that the vaccine is delivered effectively into the muscle tissue, where it can stimulate an immune response. The likelihood of accidentally injecting into a major blood vessel during this process is extremely low. The anatomy of the upper arm does not include large blood vessels in the area where the vaccine is typically administered. Therefore, the bleeding you observed is more likely due to the rupture of small capillaries or microvessels in the skin or muscle tissue rather than a direct injection into a blood vessel.

The presence of blood at the injection site, especially if it is a small amount and localized, is generally not a cause for alarm. It is often a result of minor trauma to the tissue during the injection process. Applying pressure with a cotton ball or bandage can help control any minor bleeding. If the bleeding is significant or does not stop after a few minutes of applying pressure, it would be advisable to consult a healthcare professional for further evaluation.

Regarding the concerns about potential side effects or increased risks of myocarditis (inflammation of the heart muscle), current evidence suggests that minor bleeding at the injection site does not correlate with an increased risk of serious side effects, including myocarditis. Myocarditis has been reported as a rare side effect associated with mRNA vaccines, particularly in adolescent males, but this is not linked to the injection technique or minor bleeding. The benefits of vaccination, particularly in preventing COVID-19 and its complications, far outweigh these rare risks.

In summary, while it is always prudent to monitor your child for any unusual symptoms following vaccination, minor bleeding at the injection site is typically not a cause for concern and does not increase the risk of serious side effects. If you notice any signs of excessive bleeding, unusual swelling, or if your child develops symptoms such as chest pain, shortness of breath, or persistent fever, it is essential to seek medical attention promptly.

In conclusion, vaccination is a critical tool in protecting children from infectious diseases, and while minor side effects can occur, they are generally manageable and not indicative of serious health issues. Always feel free to reach out to your healthcare provider with any concerns or questions regarding your child's vaccinations.

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