Safe Anti-Itch Creams for Individuals with Favism - Dermatology

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Patients with G6PD deficiency can use anti-itch ointments?


I have favism, and recently I've been experiencing itchy skin that initially felt like insect bites.
The itchy areas then became swollen and gradually expanded.
The doctor diagnosed it as urticaria and prescribed antihistamines and anti-itch ointment.
The anti-itch ointment is Kenalog in Orabase, and I also used a stronger ointment, C.B.
OINTMENT.
At night, I experienced sudden intense itching in the groin and scrotum, and I applied C.B.
OINTMENT for relief.
The next morning, I woke up early to play basketball, and my whole body felt somewhat weak.
This is similar to an incident years ago when I had muscle weakness, and blood tests at the hospital showed an abnormal increase in white blood cell count.
Upon reflection, I realized it was a symptom of favism.
I researched Kenalog in Orabase and C.B.
OINTMENT, and found that they are not suitable for individuals with favism.
What anti-itch ointments are appropriate for those with favism?

Wilson Wang, 60~69 year old female. Ask Date: 2022/08/03

Dr. Li Yufen reply Dermatology


Hello: For the contraindicated foods and medications related to G6PD deficiency, you can refer to the introduction by the Smiling Pharmacist at https://www.edh.tw/article/15111.
There are many types of topical anti-itch creams available; as long as you avoid the contraindicated ingredients, they can be used.
It is recommended to consult a nearby dermatologist for diagnosis and treatment, and inform them of your G6PD deficiency status to adjust your medication accordingly.
Thank you!

Reply Date: 2022/08/03

More Info


When dealing with skin conditions such as urticaria (hives) and itchiness, especially in individuals with favism (a genetic condition that leads to a deficiency in the enzyme glucose-6-phosphate dehydrogenase, or G6PD), it is crucial to choose topical treatments carefully. Favism can lead to hemolytic anemia when exposed to certain triggers, including specific medications and foods. Therefore, understanding the safety of anti-itch creams is vital for your health.

You mentioned using creams like 金貝比 (Jin Bei Bi) and 強力施美 (C.B. Ointment). While these products may provide temporary relief from itching, they might not be suitable for individuals with G6PD deficiency. Some topical medications can contain ingredients that may exacerbate the condition or lead to adverse reactions. For instance, certain topical steroids or creams with strong active ingredients can sometimes cause systemic absorption, which could be harmful for someone with favism.

For individuals with favism experiencing skin itchiness, it is advisable to opt for milder, hypoallergenic creams that do not contain potential irritants or harmful substances. Here are some recommendations:
1. Hydrocortisone Cream: A low-potency topical steroid that can help reduce inflammation and itching. It is generally considered safe for short-term use in individuals with G6PD deficiency, but it should be used sparingly and not over large areas of the body.

2. Calamine Lotion: This is a soothing lotion that can help relieve itching and discomfort from skin irritations. It is safe for use in individuals with favism and can provide a cooling effect.

3. Aloe Vera Gel: Known for its soothing properties, aloe vera can help calm irritated skin and is safe for individuals with G6PD deficiency.

4. Oatmeal Baths: Colloidal oatmeal can be added to bathwater to help soothe itchy skin. This is a natural remedy that is safe and effective for many skin conditions.

5. Moisturizers: Using a gentle, fragrance-free moisturizer can help maintain skin hydration and reduce itchiness. Look for products that are specifically labeled as hypoallergenic.

It is essential to avoid any creams that contain strong active ingredients or preservatives that could trigger an allergic reaction or exacerbate your condition. Always read the ingredient list carefully and consult with your healthcare provider or dermatologist before trying new products.

In addition to topical treatments, managing your environment can also help alleviate symptoms. Keeping your skin moisturized, avoiding known allergens, and wearing loose-fitting clothing can reduce irritation. If you experience severe itching or any other concerning symptoms, it is crucial to seek medical attention promptly.

Lastly, if you have a history of muscle weakness or abnormal blood tests related to your G6PD deficiency, it is vital to discuss these symptoms with your healthcare provider. They can help determine if there is a connection between your skin symptoms and your underlying condition, ensuring that you receive appropriate care tailored to your specific health needs.

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